Phenotypes associated with this allele

• Allele Symbol: Rr27^tm4Msb
• Allele Name: targeted mutation 4, Marisa S Bartolomei
• Allele ID: MGI:3617971
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rr27^tm4Msb/Rr27^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3620117

Genotype
MGI:3620117

ht1

• Allelic Composition: Rr27^tm4Msb/Rr27⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased embryo weight ( J:105567 )

• at E13.5, embryos are 18% heavier than controls when maternally inherited

• at E9.5, embyros are indistiguishable from controls

embryo

increased embryo weight ( J:105567 )

• at E13.5, embryos are 18% heavier than controls when maternally inherited

• at E9.5, embyros are indistiguishable from controls

increased placenta weight ( J:105567 )

• at E13.5, placentas were 40% heavier than controls when maternally inherited

• at E9.5, placenta size is similar to controls

cellular

abnormal imprinting ( J:106218 )

• when paternally inherited, the paternal H19 locus is derepressed and the paternally inherited Igf2 is repressed

• when maternally inherited, the maternal H19 gene is repressed and the Igf2 gene is activated

• embryonic methylataion of the H19 prometer and 5' end is lost