Analysis Tools
mortality/aging
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• 50% of the animals die before postnatal day 10
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growth/size/body
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• surviving homozygotes are noticeably smaller than controls (homozygous floxed littermates not carrying the Cre transgene) with normal myogenin expression
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• at 12 weeks postnatal, homozygous null animals weigh 30% less than controls; at 6 weeks of age, null mice weighed 17.5 g compared to 20 g for controls
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muscle
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• in one pair of homozygous littermates, diaphragms were notably thinner than those of controls but the animals breathed normally
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