Phenotypes associated with this allele

• Allele Symbol: Kcnq4^tm1.1Tjj
• Allele Name: targeted mutation 1.1, Thomas J Jentsch
• Allele ID: MGI:3618993
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnq4^tm1.1Tjj/Kcnq4^tm1.1Tjj	involves: 129/Sv * C57BL/6	MGI:3620097

Genotype
MGI:3620097

hm1

• Allelic Composition: Kcnq4^tm1.1Tjj/Kcnq4^tm1.1Tjj
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

cochlear outer hair cell degeneration ( J:105924 )

• at 4 weeks of age, selective degeneration of outer hair cells of the basal turn is observed; this progresses over time

• 1 year old animals exhibit a near complete loss of outer hair cells

increased or absent threshold for auditory brainstem response ( J:105924 )

• at 3 weeks, the auditory brainsterm response at higher frequency is shifted about 35 dB compared to wild-type

• at P14 animals have a higher hearing threshold than controls but at P21 the hearing ability at those frequencies approaches that of controls

sensorineural hearing loss ( J:105924 )

• after P21, animals develop a significant hearing loss

nervous system

cochlear outer hair cell degeneration ( J:105924 )

• at 4 weeks of age, selective degeneration of outer hair cells of the basal turn is observed; this progresses over time

• 1 year old animals exhibit a near complete loss of outer hair cells