Phenotypes associated with this allele

• Allele Symbol: Ccng1^tm1Sst
• Allele Name: targeted mutation 1, Snorri S Thorgeirsson
• Allele ID: MGI:3619024
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccng1^tm1Sst/Ccng1^tm1Sst	involves: 129S/SvEv * C57BL/6	MGI:3619456

Genotype
MGI:3619456

hm1

• Allelic Composition: Ccng1^tm1Sst/Ccng1^tm1Sst
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased hepatoma incidence ( J:106007 )

• only 14% of male homozygous mutants develop hepatocellular tumors by 16-18 months of age compared with 20% age and sex matched controls

• in 14-day old male mutant and control littermates inject with N-diethylnitrosamine to induce tumors, 50% of wild-type mice and 20% of mutant mice showed hepatic tumors at 25-weeks post-injection; at 36 weeks after treatment, all wild-type and 90% of mutant mice developed tumors

• only 5% of female mutants treated with N-diethynitrosamine develop hepatic tumors by 3 weeks compared to 90% of treated wild-type females

increased hepatoma incidence ( J:106007 )

• treated male mutants show reduced size and lower numbers of tumors than treated wild-type

decreased incidence of induced tumors ( J:106007 )

• tumor multiplicity in mutant mice in response to carcinogen is 4-fold lower than in wild-type

liver/biliary system

decreased liver weight ( J:106007 )

• liver mass is 2-fold lower in carcinogen-treated mutant mice

decreased hepatoma incidence ( J:106007 )

• only 14% of male homozygous mutants develop hepatocellular tumors by 16-18 months of age compared with 20% age and sex matched controls

• in 14-day old male mutant and control littermates inject with N-diethylnitrosamine to induce tumors, 50% of wild-type mice and 20% of mutant mice showed hepatic tumors at 25-weeks post-injection; at 36 weeks after treatment, all wild-type and 90% of mutant mice developed tumors

• only 5% of female mutants treated with N-diethynitrosamine develop hepatic tumors by 3 weeks compared to 90% of treated wild-type females

increased hepatoma incidence ( J:106007 )

• treated male mutants show reduced size and lower numbers of tumors than treated wild-type

abnormal liver regeneration ( J:106007 )

• after partial hepatectomy, livers in mutant mice treated with Dipin to induce DNA damage have a considerably lower DNA labeling index compared to wild-type-Dipin PH livers