Phenotypes associated with this allele

• Allele Symbol: Tg(GFAP-TVA)10Ech
• Allele Name: transgene insertion 10, Eric C Holland
• Allele ID: MGI:3619228
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(GFAP-TVA)10Ech/0	involves: 129 * BALB/c * C57BL/6 * FVB/N * SJL	MGI:3835350
tg2	Tg(GFAP-TVA)10Ech/0	involves: 129 * BALB/c * C57BL/6 * FVB/N	MGI:3835349

Genotype
MGI:3835350

cx1

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; Tg(GFAP-TVA)10Ech/0
• Genetic Background: involves: 129 * BALB/c * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased glioma incidence ( J:52161 )

• 2 of 6 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR develop gliomas unlike similarly treated wild-type mice

hydrocephaly ( J:52161 )

• at 6 weeks, mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR develop hydrocephalus

neoplasm

increased glioma incidence ( J:52161 )

• 2 of 6 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR develop gliomas unlike similarly treated wild-type mice

Genotype
MGI:3835349

tg2

• Allelic Composition: Tg(GFAP-TVA)10Ech/0
• Genetic Background: involves: 129 * BALB/c * C57BL/6 * FVB/N

neoplasm

neoplasm ( J:52161 )

N • mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR do not develop gliomas