neoplasm
• mice exhibit accelerated tumorigenesis compared with Tg(IGL-MYC)3Hm mice
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Allele Symbol Allele Name Allele ID |
Tg(IGL-MYC)3Hm transgene insertion 3, Herbert Morse MGI:3619458 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit accelerated tumorigenesis compared with Tg(IGL-MYC)3Hm mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit accelerated tumorigenesis compared with Tg(IGL-MYC)3Hm mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• most mice hemizygous for the transgene die between the ages of 2 and 6 months
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• transgene hemizygotes develop severe lymphadenopathy, but only minimal splenomegaly
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• hemizygous transgenics develop clonal B-lineage lymphomas; their spleens and lymph nodes contain "uniform populations of IgM+CD19+CD5-CD23- cells"
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Burkitt lymphoma | DOID:8584 |
OMIM:113970 |
J:65245 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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