Phenotypes associated with this allele

• Allele Symbol: Ing1^tm1Avg
• Allele Name: targeted mutation 1, A V Gudkov
• Allele ID: MGI:3619526
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ing1^tm1Avg/Ing1^tm1Avg	involves: 129S1/Sv * C57BL/6	MGI:3619848

Genotype
MGI:3619848

hm1

• Allelic Composition: Ing1^tm1Avg/Ing1^tm1Avg
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:105658 )

• mortality is increased after exposure to 6 consecutive daily doses of 2.34 Gy; however, mortality after exposure to a single dose of 11 Gy or 15 Gy is similar to wild-type

premature death ( J:105658 )

• during a 23 month observation period more homozygotes (35.6%) showed signs of morbidity or visible abnormalities compared to wild-type littermates (20.8%)

neoplasm

increased B cell derived lymphoma incidence ( J:105658 )

• 9 of 42 homozygotes developed lymphomas most of which were classified as follicular center B-cell lymphomas

• most of these lymphomas were composed of a pleomorphic population of small lymphocytes, centrocytes, centroblasts, and follicular center cells

• most neoplastic lymphocytes were found in the spleen with some also detected in the liver, kidney, lungs and mesentrial and mediastinal lymph nodes

immune system

enlarged spleen ( J:105658 )

• some homozygotes develop splenomegaly with enlarged white pulp areas that can be associated with B-cell derived lymphoma

cellular

abnormal cell cycle ( J:105658 )

• slight but consistent decrease in the proportion of cells in G2 after treatment with UV-B, doxorubicine, or taxol

increased cellular sensitivity to ultraviolet irradiation ( J:105658 )

• slight but consistent increase in sensitivity to UV-B induced cell death; however MEF lifespan in culture in the absence of treatment is similar to wild-type

behavior/neurological

abnormal maternal nurturing ( J:105658 )

♀ • in 6 of 13 litters homozygous females showed a tendency to neglect or destroy their pups compared to 1 of 19 litters for wild-type females

growth/size/body

decreased body weight ( J:105658 )

• body weight is decreased by 10% and 20% in homozygous males and females, respectively, compared to sex matched wild-type mice

enlarged spleen ( J:105658 )

• some homozygotes develop splenomegaly with enlarged white pulp areas that can be associated with B-cell derived lymphoma

hematopoietic system

enlarged spleen ( J:105658 )

• some homozygotes develop splenomegaly with enlarged white pulp areas that can be associated with B-cell derived lymphoma

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:105658 )

• mortality is increased after exposure to 6 consecutive daily doses of 2.34 Gy; however, mortality after exposure to a single dose of 11 Gy or 15 Gy is similar to wild-type