Phenotypes associated with this allele

• Allele Symbol: Aifm2^tm1Hbsh
• Allele Name: targeted mutation 1, H B Shu
• Allele ID: MGI:3619528
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aifm2^tm1Hbsh/Aifm2^tm1Hbsh	involves: 129S6/SvEvTac	MGI:3619718

Genotype
MGI:3619718

hm1

• Allelic Composition: Aifm2^tm1Hbsh/Aifm2^tm1Hbsh
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell proliferation ( J:105660 )

• homozygous MEFs are less sensitive to genotoxin (doxorubicin, 5-fluorouracil, or etoposide) induced growth inhibition

• however, genotoxin induced apoptosis is similar to wild-type

neoplasm

neoplasm ( J:105660 )

N • no increase in spontaneous tumors or change in MCA-induced sarcoma incidence are seen and homozygous mice are viable and fertile with no gross abnormalities