Phenotypes associated with this allele

• Allele Symbol: Gjc3^tm1Paul
• Allele Name: targeted mutation 1, David L Paul
• Allele ID: MGI:3619604
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gjc3^tm1Paul/Gjc3^tm1Paul	involves: 129S4/SvJae	MGI:3621926

Genotype
MGI:3621926

hm1

• Allelic Composition: Gjc3^tm1Paul/Gjc3^tm1Paul
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal auditory brainstem response waveform shape ( J:105700 )

• latencies of click-evoked ABRs are significantly delayed at all sound intensities

increased or absent threshold for auditory brainstem response ( J:105700 )

• 55% of null mice show increased auditory thresholds at 3 weeks of age; after 6 weeks, hearing thresholds of most mice developed into the thresholds of controls

• when tested at 6 months of age, 50% of null mice show hearing threshold elevation at higher frequencies

increased susceptibility to noise-induced hearing loss ( J:105700 )

• 6 week old null mice are more vulnerable to noise damage than wild-type

nervous system

demyelination ( J:105700 )

• demyelination is observed around the soma of spiral ganglion neurons of null mice; in addition, vacuolation below the cell membrane is observed