Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Myh6-Pik3r1/PIK3CA)BSiz transgene insertion B, Seigo Izumo MGI:3619920 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• heart weight/body weight ratio is increased to a similar extent as in single Tg(Myh6-Pik3r1/PIK3CA)BSiz mice
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• heart weight/body weight ratio is increased to a similar extent as in single Tg(Myh6-Pik3r1/PIK3CA)BSiz mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• exhibit a significant increase in heart size, with an increase in the heart weight/body weight ratio
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• exhibit a significant increase in heart size, with an increase in the heart weight/body weight ratio
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• myocytes exhibit a 19% increase in mean cell size, with both the long and short axis lengths increased
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• hearts are about 20% larger
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• heart weight/body weight ratio is increased by 18% without changes in the size of other organs or overall body weight, however show no signs of heart failure after 1 year
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• significant increase in wall thickness in both the anterior and the posterior left ventricular (LV) walls, however observe no differences in LV diastolic or systolic diameter or fractional shortening, indicating normal cardiac function
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• mice subjected to pressure overload with aortic banding exhibit protection against pressure overload, with a trend for a reduction in left ventricle end-systolic volume and greater systolic function, blunted cardiac hypertrophy, reduced left ventricle chamber dimension, and decreased fibrosis in the left ventricular wall
• however, mice exhibit a hypertrophic response to swim exercise training similar to controls
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• mice subjected to pressure overload with aortic banding exhibit protection against pressure overload, with a trend for a reduction in left ventricle end-systolic volume and greater systolic function, blunted cardiac hypertrophy, reduced left ventricle chamber dimension, and decreased fibrosis in the left ventricular wall
• however, mice exhibit a hypertrophic response to swim exercise training similar to controls
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• myocytes exhibit a 19% increase in mean cell size, with both the long and short axis lengths increased
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• hearts are about 20% larger
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• heart weight/body weight ratio is increased by 18% without changes in the size of other organs or overall body weight, however show no signs of heart failure after 1 year
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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