Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Myh6-Pik3ca)1Siz transgene insertion 1, Seigo Izumo MGI:3619921 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• display a reduction in heart size similar to that seen in single Tg(Myh6-Pik3ca)1Siz mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• heart weight/body weight ratio is increased to a similar extent as in single Tg(Myh6-Pik3r1/PIK3CA)BSiz mice
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• heart weight/body weight ratio is increased to a similar extent as in single Tg(Myh6-Pik3r1/PIK3CA)BSiz mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the heart weight/body weight ratio is significantly lower than in single Tg(Myh6-IGF1R)7Siz mice and not different from single Tg(Myh6-Pik3ca)1Siz mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the heart weight/body weight ratio is similar to that of single Tg(Myh6-Akt1*T308D*S473D)1Siz mice
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• the heart weight/body weight ratio is similar to that of single Tg(Myh6-Akt1*T308D*S473D)1Siz mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit shortened lifespan compared to single Tg(Myh6-cre)TG9Pjay transgenic mice
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• mice exhibit accelerated progression of heart failure compared to single Tg(Myh6-cre)TG9Pjay transgenic mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• myocytes exhibit an 18% decrease in mean cell size, with both the long and short axis lengths decreased
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• heart weight/body weight ratio is decreased by 17% without changes in the size of other organs or overall body weight, however show no signs of heart failure or abnormal cardiac function after 1 year
(J:62707)
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• mice subjected to pressure overload with aortic banding exhibit an increase in left ventricle end-systolic and diastolic volumes and depressed systolic function, exaggerated cardiac hypertrophy, increased left ventricle chamber dimension, and increased cardiac fibrosis in the left ventricular wall
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• mice subjected to pressure overload with aortic banding exhibit an increase in left ventricle end-systolic and diastolic volumes and depressed systolic function, exaggerated cardiac hypertrophy, increased left ventricle chamber dimension, and increased cardiac fibrosis in the left ventricular wall
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• myocytes exhibit an 18% decrease in mean cell size, with both the long and short axis lengths decreased
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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