Phenotypes associated with this allele

• Allele Symbol: Scd1^flk
• Allele Name: flake
• Allele ID: MGI:3620028
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scd1^flk/Scd1^flk	C57BL/6J-Scd1^flk	MGI:3620030

Genotype
MGI:3620030

hm1

• Allelic Composition: Scd1^flk/Scd1^flk
• Genetic Background: C57BL/6J-Scd1^flk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

sebaceous gland atrophy ( J:100424 )

abnormal sebaceous lipid secretion ( J:100424 )

• cholesterol ester content of lipid extracts from skin of homozygous mutant mice is reduced

immune system

increased susceptibility to bacterial infection ( J:100424 )

• homozygous mutant mice have impaired ability to clear subcutaneously injected gram-positive (Streptococcus pyogenes and Staphylococcus aureus) but not gram-negative (E. coli) bacteria or intravenously or intrapulmonarily administered gram-positive bacteria (Listeria monocytogenes and S. aureus, respectively)

• repeated injection of palmitoleate following intradermal infection with luminescent S. aureus reduced local luminescence by 90% and ulcer size by 75% by post-infection day 9 in wild-type mice, but even at higher doses had a much less pronounced, though significant, effect in mutant mice

integument

sebaceous gland atrophy ( J:100424 )

abnormal sebaceous lipid secretion ( J:100424 )

• cholesterol ester content of lipid extracts from skin of homozygous mutant mice is reduced

alopecia ( J:100424 )

• first noticeable at weaning and progressing as mice age

flaky skin ( J:100424 )

• chronic exfoliative dermatitis

scaly skin ( J:100424 )

spontaneous skin ulceration ( J:100424 )

• epidermal integrity of mutant mice becomes visibly disrupted