Phenotypes associated with this allele

• Allele Symbol: Mylk^tm1Avs
• Allele Name: targeted mutation 1, A V Somlyo
• Allele ID: MGI:3620051
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mylk^tm1Avs/Mylk^tm1Avs	B6.129-Mylk^tm1Avs	MGI:3620767

Genotype
MGI:3620767

hm1

• Allelic Composition: Mylk^tm1Avs/Mylk^tm1Avs
• Genetic Background: B6.129-Mylk^tm1Avs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle contractility ( J:106058 )

• the pCa force curve is shifted left by 0.3 pCa units in alpha-toxin permeabilized ileal smooth muscle but not in aorta smooth muscle

abnormal muscle relaxation ( J:106058 )

• 8-Br-cGMP-induced muscle relaxation is impaired in alpha-toxin permeabilized ileal smooth muscle precontracted with pCA 6.3

• however, the array of myosin filaments in longitudinal muscle from the ileum is normal