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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgfr1tm3.1Sor
targeted mutation 3.1, Philippe Soriano
MGI:3620057
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fgfr1tm3.1Sor/Fgfr1tm3.1Sor involves: 129S4/SvJaeSor * C57BL/6J MGI:3620072
cn2
 		Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Frs3tm1Jheb/Frs3tm1Jheb 		involves: 129 MGI:6116893
cn3
 		Fgfr2tm1Dor/Fgfr2tm1Dor
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm3.1Sor/Fgfr1tm1Jpa 		involves: 129 MGI:6116896


Genotype
MGI:3620072
hm1
Allelic
Composition		 Fgfr1tm3.1Sor/Fgfr1tm3.1Sor
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm3.1Sor mutation (0 available); any Fgfr1 mutation (223 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:105920 )
• no homozygous animals are recovered postnatally; embryos survive to E15.5 then display a drop in viability

embryo
embryonic growth retardation ( J:105920 )
• embryos are delayed by about 1 day
abnormal neural tube closure ( J:105920 )
• 30-50% of embryos isolated at E10.5-11.5 have a defect in spinal neural tube closure; in some, the neural tube remained completely open, while in others it is closed at discrete points with the intervening regions remaining open
spina bifida ( J:105920 )
• later in development, some embryos display spina bifida

nervous system
abnormal neural tube closure ( J:105920 )
• 30-50% of embryos isolated at E10.5-11.5 have a defect in spinal neural tube closure; in some, the neural tube remained completely open, while in others it is closed at discrete points with the intervening regions remaining open
spina bifida ( J:105920 )
• later in development, some embryos display spina bifida

growth/size/body
embryonic growth retardation ( J:105920 )
• embryos are delayed by about 1 day




Genotype
MGI:6116893
cn2
Allelic
Composition		 Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Frs3tm1Jheb/Frs3tm1Jheb
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr1tm3.1Sor mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Fgfr3tm6.1Cxd mutation (0 available); any Fgfr3 mutation (54 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Frs3tm1Jheb mutation (0 available); any Frs3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:242687 )
N
• cell division at E8.75 according to mitotic marker p-HH3 immunoreactivity
increased cell death ( J:242687 )
• according to TUNEL assay at E8.75

nervous system




Genotype
MGI:6116896
cn3
Allelic
Composition		 Fgfr2tm1Dor/Fgfr2tm1Dor
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr1tm3.1Sor mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial

nervous system
telencephalon hypoplasia ( J:242687 )
• reduction in size across A/P and D/V axes at E12.5
abnormal lateral ganglionic eminence morphology ( J:242687 )
• absent at E13.5 according to lack of Lhx8- and Nkx2-1-labeling of LGE region
abnormal medial ganglionic eminence morphology ( J:242687 )
• absent at E13.5 according to lack of Lhx8- and Nkx2-1-labeling of MGE region

vision/eye
microphthalmia ( J:242687 )
• at E12.5




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory