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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgfr1tm5.1Sor
targeted mutation 5.1, Philippe Soriano
MGI:3620060
Summary 4 genotypes


Genotype
MGI:5882546
cn1
Allelic
Composition		 Fgfr1tm5.1Sor/Fgfr1tm10.1Sor
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 129S4.Cg-Fgfr1tm5.1Sor Fgfr1tm10.1Sor H2az2Tg(Wnt1-cre)11Rth
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm10.1Sor mutation (1 available); any Fgfr1 mutation (223 available)
Fgfr1tm5.1Sor mutation (0 available); any Fgfr1 mutation (223 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:226497 )
• at P0, 2 of 13 mice exhibit clefting of the palatine and palatal process of the maxilla

growth/size/body
cleft palate ( J:226497 )
• at P0, 2 of 13 mice exhibit clefting of the palatine and palatal process of the maxilla

digestive/alimentary system
cleft palate ( J:226497 )
• at P0, 2 of 13 mice exhibit clefting of the palatine and palatal process of the maxilla




Genotype
MGI:5882544
cn2
Allelic
Composition		 Fgfr1tm5.1Sor/Fgfr1tm9.1Sor
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 129S4.Cg-Fgfr1tm5.1Sor Fgfr1tm9.1Sor H2az2Tg(Wnt1-cre)11Rth
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm5.1Sor mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr1tm9.1Sor mutation (1 available); any Fgfr1 mutation (223 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:226497 )
• at P0, 1 of 7 mice exhibit clefting of the palatine and palatal process of the maxilla

growth/size/body
cleft palate ( J:226497 )
• at P0, 1 of 7 mice exhibit clefting of the palatine and palatal process of the maxilla

digestive/alimentary system
cleft palate ( J:226497 )
• at P0, 1 of 7 mice exhibit clefting of the palatine and palatal process of the maxilla




Genotype
MGI:5882528
cn3
Allelic
Composition		 Fgfr1tm5.1Sor/Fgfr1tm5.1Sor
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 129S4.Cg-Fgfr1tm5.1Sor H2az2Tg(Wnt1-cre)11Rth
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm5.1Sor mutation (0 available); any Fgfr1 mutation (223 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
midline facial cleft ( J:226497 )
• at P0, all (16 of 16) mice exhibit midline facial clefting

growth/size/body
midline facial cleft ( J:226497 )
• at P0, all (16 of 16) mice exhibit midline facial clefting




Genotype
MGI:5882547
cn4
Allelic
Composition		 Fgfr1tm5.1Sor/Fgfr1tm10.1Sor
Stat3tm2Aki/Stat3tm2Aki
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm10.1Sor mutation (1 available); any Fgfr1 mutation (223 available)
Fgfr1tm5.1Sor mutation (0 available); any Fgfr1 mutation (223 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Stat3tm2Aki mutation (1 available); any Stat3 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
craniofacial phenotype ( J:226497 )
N
• none of the 4 mice examined exhibit cleft palate, likely due to the low penetrance of cleft palate found in Fgfr1tm5.1Sor/Fgfr1tm10.1Sor mice (2 of 13)




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory