Phenotypes associated with this allele

• Allele Symbol: Peg10^tm1Fuis
• Allele Name: targeted mutation 1, Fumitoshi Ishino
• Allele ID: MGI:3620548
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Peg10^tm1Fuis/Peg10^+	involves: 129S/SvEv	MGI:3620652

Genotype
MGI:3620652

ht1

• Allelic Composition: Peg10^tm1Fuis/Peg10⁺
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:106134 )

• heterozygotes with a paternally inherited allele die around E10.5; however, about 50% of tetraploid rescue embryos and all heterozygotes with a maternally inherited allele survive

embryo

embryonic growth retardation ( J:106134 )

• heterozygotes with a paternally inherited allele become severely growth retarded between E9.5 and E10.5

• tetraploid rescue embryos with a paternally inherited allele also show growth retardation

abnormal spongiotrophoblast cell morphology ( J:106134 )

• in heterozygotes with a paternally inherited allele spongiotrophoblast cells are absent at E9.5 and E10.5; however, trophoblast giant cells are present

absent placental labyrinth ( J:106134 )

• in heterozygotes with a paternally inherited allele

small placenta ( J:106134 )

• in heterozygotes with a paternally inherited allele the placenta is slightly smaller at E9.5 and severely depleted at E10.5, but no differences are seen at E7.5 or E8.5

growth/size/body

embryonic growth retardation ( J:106134 )

• heterozygotes with a paternally inherited allele become severely growth retarded between E9.5 and E10.5

• tetraploid rescue embryos with a paternally inherited allele also show growth retardation

cellular

maternal imprinting ( J:106134 )

• heterozygotes with a paternally inherited allele die around E10.5 while heterozygotes with a maternally inherited allele are viable and fertile