Phenotypes associated with this allele

• Allele Symbol: Cdkn1b^tm2Kin
• Allele Name: targeted mutation 2, Kei-ichi Nakayama
• Allele ID: MGI:3620550
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cdkn1b^tm2Kin/Cdkn1b^tm2Kin Rassf5^tm1Kina/Rassf5^tm1Kina	involves: C57BL/6 * CBA	MGI:4939905

Genotype
MGI:4939905

cx1

• Allelic Composition: Cdkn1b^tm2Kin/Cdkn1b^tm2Kin; Rassf5^tm1Kina/Rassf5^tm1Kina
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:168749 )

N • development of glomerulonephritis that is observed in single Rassf5 homozygotes is suppressed, in addition, CD138+B220+ plasma cells are reduced by 67%, CD44+CD62L- effector-memory T cells are reduced by 28%, and titers of antibodies to dsDNA are decreased by 58% compared to single Rassf5 homozygotes and deposition of IgG in the kidney is rarely detected compared to single Rassf5 homozygotes

homeostasis/metabolism

increased urine protein level ( J:168749 )

• incidence of proteinuria is reduced (22%) compared to single Rassf5 homozygotes (63%)

renal/urinary system

increased urine protein level ( J:168749 )

• incidence of proteinuria is reduced (22%) compared to single Rassf5 homozygotes (63%)

neoplasm

neoplasm ( J:168749 )

N • mutants do not develop B cell lymphomas or other tumors