Phenotypes associated with this allele

• Allele Symbol: Tg(Cdh5-cre)7Mlia
• Allele Name: transgene insertion 7, M Luisa Iruela-Arispe
• Allele ID: MGI:3620560
• Summary: 23 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Abcc6^tm1c(EUCOMM)Wtsi/Abcc6^tm1c(EUCOMM)Wtsi Tg(Cdh5-cre)7Mlia/?	B6.Cg-Abcc6^tm1c(EUCOMM)Wtsi Tg(Cdh5-cre)7Mlia	MGI:6241514
cn2	Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Tg(Cdh5-cre)7Mlia/0	B6.Cg-Egln1^tm2.1Fsl Tg(Cdh5-cre)7Mlia	MGI:5525142
cn3	Jag1^tm1Frad/Jag1^tm1Frad Tg(Cdh5-cre)7Mlia/0	B6.Cg-Jag1^tm1Frad Tg(Cdh5-cre)7Mlia	MGI:5447166
cn4	Podxl^tm2Kmn/Podxl^tm2Kmn Tg(Cdh5-cre)7Mlia/0	B6.Cg-Podxl^tm2Kmn Tg(Cdh5-cre)7Mlia	MGI:5781207
cn5	Notch1^tm1Agt/Notch1^tm1Agt Tg(Cdh5-cre)7Mlia/0 Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^+	involves: 129 * 129S4/SvJaeSor * FVB/N	MGI:5447168
cn6	Jag1^tm1Frad/Jag1^tm1Frad Tg(Cdh5-cre)7Mlia/0 Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^+	involves: 129 * 129S4/SvJaeSor * FVB/N	MGI:5447167
cn7	Senp1^tm1Wami/Senp1^tm1Wami Tg(Cdh5-cre)7Mlia/0	involves: 129 * C57BL/6 * FVB/N	MGI:5707798
cn8	Jam3^tm1.1Chav/Jam3^tm1.2Chav Tg(Cdh5-cre)7Mlia/?	involves: 129 * C57BL/6 * FVB/N	MGI:5140203
cn9	F8^tm1.1Rmnt/F8^tm1.1Rmnt Tg(Cdh5-cre)7Mlia/0	involves: 129 * C57BL/6 * FVB/N * SJL	MGI:5582834
cn10	Ctnnb1^tm2Kem/Ctnnb1^+ Pten^tm1Hwu/Pten^tm1Hwu Tg(Cdh5-cre)7Mlia/0	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N	MGI:4839562
cn11	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Pten^tm1Hwu/Pten^tm1Hwu Tg(Cdh5-cre)7Mlia/0	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N	MGI:4839561
cn12	Rapgef2^tm1.1Hous/Rapgef2^tm1.1Hous Tg(Cdh5-cre)7Mlia/0	involves: 129S1/Sv * FVB/N	MGI:4839187
cn13	Pten^tm1Hwu/Pten^tm1Hwu Tg(Cdh5-cre)7Mlia/0	involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N	MGI:4839560
cn14	Mcur1^tm1c(KOMP)Wtsi/Mcur1^tm1c(KOMP)Wtsi Tg(Cdh5-cre)7Mlia/0	involves: 129S4/SvJaeSor * C57BL/6N * FVB/N	MGI:5912150
cn15	Dcbld2^tm1Mhms/Dcbld2^tm1.1Mhms Tg(Cdh5-cre)7Mlia/0	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:5569330
cn16	Mcu^tm1.1Jmol/Mcu^tm1.1Jmol Tg(Cdh5-cre)7Mlia/0	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:5912151
cn17	Acvr1^tm1Glh/Acvr1^+ Tg(Cdh5-cre)7Mlia/0	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:7278770
cn18	H2ax^tm1Nus/H2ax^tm2.1Fwa Tg(Cdh5-cre)7Mlia/0	involves: 129S6/SvEvTac * FVB/N	MGI:3849332
cn19	Pgr^tm1.1Mlia/Pgr^tm1.1Mlia Tg(Cdh5-cre)7Mlia/0	involves: 129X1/SvJ * FVB/N	MGI:5566877
cn20	Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre)7Mlia/0	involves: C57BL/6J * FVB/N	MGI:5477819
cn21	Adora2b^tm1Msit/Adora2b^tm1Msit Tg(Cdh5-cre)7Mlia/0	involves: FVB/N	MGI:6151086
cn22	Bicra^em3Hzhg/Bicra^em3Hzhg Tg(Cdh5-cre)7Mlia/0	involves: FVB/N	MGI:7543772
tg23	Tg(Cdh5-cre)7Mlia/0	involves: FVB/N	MGI:3665410

Genotype
MGI:6241514

cn1

• Allelic Composition: Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi}; Tg(Cdh5-cre)7Mlia/?
• Genetic Background: B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Cdh5-cre)7Mlia

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

integument phenotype ( J:252837 )

N • no calcification occurs in the fibrous capsule surrounding the muzzle vibrissae

Genotype
MGI:5525142

cn2

• Allelic Composition: Egln1^tm2.1Fsl/Egln1^tm2.1Fsl; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: B6.Cg-Egln1^tm2.1Fsl Tg(Cdh5-cre)7Mlia

cardiovascular system

increased heart weight ( J:202737 )

• increased cardiac mass as compared to controls

mortality/aging

premature death ( J:202737 )

• less than half of mice survive to 6 months of age

growth/size/body

increased heart weight ( J:202737 )

• increased cardiac mass as compared to controls

Genotype
MGI:5447166

cn3

• Allelic Composition: Jag1^tm1Frad/Jag1^tm1Frad; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: B6.Cg-Jag1^tm1Frad Tg(Cdh5-cre)7Mlia

growth/size/body

heart right ventricle hypertrophy ( J:189213 )

mortality/aging

mortality/aging ( J:166890 )

N • contrary to previous reports, viable mice are produced

cardiovascular system

abnormal pulmonary trunk morphology ( J:189213 )

• abnormal positioning of the aorta and pulmonary trunk

abnormal aorta morphology ( J:189213 )

• abnormal positioning of the aorta and pulmonary trunk

abnormal cardiac outflow tract development ( J:189213 )

abnormal heart morphology ( J:189213 )

abnormal coronary vessel morphology ( J:189213 )

• fragile and hemorrhaging in embryos and neonates

• thin and disorganized

overriding aortic valve ( J:189213 )

increased heart right atrium size ( J:189213 )

• hypertrophy

ventricular septal defect ( J:189213 )

• incomplete at E14.5

abnormal heart valve morphology ( J:189213 )

• large and hyperplastic (myxomatous)

• neonates exhibit bulges near the valve annulus

• cartilage nodules and calcification in the annulus of adults

calcified aortic valve ( J:189213 )

pulmonary valve stenosis ( J:189213 )

thick heart valve cusps ( J:189213 )

• thick at P10 with lower nuclear density indicating changes in the extracellular matrix rather than increase in cell density

• increased outflow tract valve leaflet width in adults

increased heart right ventricle size ( J:189213 )

• increased area

heart right ventricle hypertrophy ( J:189213 )

increased heart right ventricle wall thickness ( J:189213 )

dilated heart ( J:189213 )

• near the apex

pulmonary valve regurgitation ( J:189213 )

• severe

increased systemic arterial systolic blood pressure ( J:189213 )

• with severe regurgitation at the pulmonic valve

muscle

heart right ventricle hypertrophy ( J:189213 )

liver/biliary system

liver/biliary system phenotype ( J:166890 )

N • mice exhibit normal bile duct formation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alagille syndrome		DOID:9245	OMIM:118450 OMIM:610205	J:189213

Genotype
MGI:5781207

cn4

• Allelic Composition: Podxl^tm2Kmn/Podxl^tm2Kmn; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: B6.Cg-Podxl^tm2Kmn Tg(Cdh5-cre)7Mlia

cardiovascular system

decreased lung endothelial cell adhesion ( J:223453 )

• isolated primary mouse pulmonary endothelial cells (mECs) display a severely impaired ability to spread on laminin and, to a lesser extent, collagen I coated transwells

increased lung endothelial cell adhesion ( J:223453 )

• isolated primary mouse pulmonary endothelial cells (mECs) show a significant increase in static adhesion to fibronectin but not to laminin, collagen (type I or type IV) or gelatin relative to control cells

• however, mECs spread normally when plated on fibronectin-coated transwells

increased vascular permeability ( J:223453 )

• 2-fold increase in basal lung vascular permeability, as shown by Evans blue dye vascular leakage assays on naive mice

• additional increase in inflammation-induced lung vascular permeability following intra-tracheal LPS treatment

• however, no detectable changes in the ratio of wet/dry lung weight, in vascular density, or in the frequency and phenotype of endothelial cells relative to controls

respiratory system

decreased lung endothelial cell adhesion ( J:223453 )

• isolated primary mouse pulmonary endothelial cells (mECs) display a severely impaired ability to spread on laminin and, to a lesser extent, collagen I coated transwells

increased lung endothelial cell adhesion ( J:223453 )

• isolated primary mouse pulmonary endothelial cells (mECs) show a significant increase in static adhesion to fibronectin but not to laminin, collagen (type I or type IV) or gelatin relative to control cells

• however, mECs spread normally when plated on fibronectin-coated transwells

abnormal lung morphology ( J:223453 )

• mislocalization of structural matrix proteins in the lung

overexpanded pulmonary alveolus ( J:223453 )

• increase in airspace size upon lung inflation at a fixed pressure with an open thoracic cavity, as shown by increased mean linear intercept (MLI) at 10 weeks but not at 1-3 weeks of age

• however, normal sized airspace and alveolar architecture upon lung inflation with a constant volume under closed chest conditions at 10 weeks of age

abnormal pulmonary collagen fibril morphology ( J:223453 )

• >30% increase in elastin-free fibrillar collagen fibers in alveolar lung tissue, primarily in larger alveolar spaces

abnormal pulmonary elastic fiber morphology ( J:223453 )

• density of elastin fiber staining is marginally decreased within lung parenchyma tissue as shown by Gomoris aldehyde fuchsin staining, despite an observed increase in elastin transcript levels

abnormal lung volume ( J:223453 )

• increase in mean lung volume upon inflation at constant pressure with an open thoracic cavity at 4 and 10 weeks of age

increased airway resistance ( J:223453 )

• increased total lung and airway resistance under closed chest conditions

• however, no significant alterations in total lung capacity or compliance

cellular

decreased lung endothelial cell adhesion ( J:223453 )

• isolated primary mouse pulmonary endothelial cells (mECs) display a severely impaired ability to spread on laminin and, to a lesser extent, collagen I coated transwells

increased lung endothelial cell adhesion ( J:223453 )

• isolated primary mouse pulmonary endothelial cells (mECs) show a significant increase in static adhesion to fibronectin but not to laminin, collagen (type I or type IV) or gelatin relative to control cells

• however, mECs spread normally when plated on fibronectin-coated transwells

Genotype
MGI:5447168

cn5

• Allelic Composition: Notch1^tm1Agt/Notch1^tm1Agt; Tg(Cdh5-cre)7Mlia/0; Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

cardiovascular system

abnormal cardiac epithelial to mesenchymal transition ( J:189213 )

• arrested

abnormal atrioventricular cushion morphology ( J:189213 )

• at E10.5, atrioventricular cushions exhibit rounded endocardial-derived cells that accumulate at the cushion interface and less dense, hypoplastic areas unlike in control mice

Genotype
MGI:5447167

cn6

• Allelic Composition: Jag1^tm1Frad/Jag1^tm1Frad; Tg(Cdh5-cre)7Mlia/0; Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129 * 129S4/SvJaeSor * FVB/N

cardiovascular system

abnormal cardiac epithelial to mesenchymal transition ( J:189213 )

• temporarily delayed at E10.5

abnormal atrioventricular cushion morphology ( J:189213 )

• at E10.5, atrioventricular cushions exhibit rounded endocardial-derived cells that accumulate at the cushion interface and less dense, hypoplastic areas unlike in control mice

Genotype
MGI:5707798

cn7

• Allelic Composition: Senp1^tm1Wami/Senp1^tm1Wami; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:228009 )

N • mice do not develop hyperglycemia even at 14 weeks of age

Genotype
MGI:5140203

cn8

• Allelic Composition: Jam3^tm1.1Chav/Jam3^tm1.2Chav; Tg(Cdh5-cre)7Mlia/?
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

neoplasm

decreased metastatic potential ( J:173391 )

• significantly reduced B16 melanoma lung metastasis

Genotype
MGI:5582834

cn9

• Allelic Composition: F8^tm1.1Rmnt/F8^tm1.1Rmnt; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

homeostasis/metabolism

decreased circulating factor VIII level ( J:212401 )

Genotype
MGI:4839562

cn10

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1⁺; Pten^tm1Hwu/Pten^tm1Hwu; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N

mortality/aging

premature death ( J:135172 )

• die before P68 with vascular complications

hematopoietic system

abnormal definitive hematopoiesis ( J:135172 )

• 100% of mutants develop myeloproliferative disorder at about P30

cardiovascular system

abnormal blood vessel morphology ( J:135172 )

• mutants exhibit vascular complication

Genotype
MGI:4839561

cn11

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem; Pten^tm1Hwu/Pten^tm1Hwu; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c * C57BL/6 * FVB/N

mortality/aging

embryonic lethality, complete penetrance ( J:135172 )

• embryonic lethal

Genotype
MGI:4839187

cn12

• Allelic Composition: Rapgef2^tm1.1Hous/Rapgef2^tm1.1Hous; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: 129S1/Sv * FVB/N

hematopoietic system

hematopoietic system phenotype ( J:165879 )

N • mice exhibit normal adult hematopoiesis

immune system

immune system phenotype ( J:165879 )

N • mice exhibit normal B cell and T cell development

Genotype
MGI:4839560

cn13

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

hematopoietic system

enlarged thymus ( J:135172 )

• 70% of mutants exhibit enlarged thymus

enlarged spleen ( J:135172 )

• splenomegaly

abnormal definitive hematopoiesis ( J:135172 )

• progressive development of myeloproliferative disorder and leukemogenesis in the chronic phase followed by blast crisis

increased leukocyte cell number ( J:135172 )

• 2-3 months after birth, mutants show increased circulating neutrophils and white blood cells and leukemic blast invasion into hematopoietic and non-hematopoietic organs

increased neutrophil cell number ( J:135172 )

• one month after birth, mutants develop a myeloid shift with increased neutrophil counts

immune system

enlarged thymus ( J:135172 )

• 70% of mutants exhibit enlarged thymus

enlarged spleen ( J:135172 )

• splenomegaly

increased leukocyte cell number ( J:135172 )

• 2-3 months after birth, mutants show increased circulating neutrophils and white blood cells and leukemic blast invasion into hematopoietic and non-hematopoietic organs

increased neutrophil cell number ( J:135172 )

• one month after birth, mutants develop a myeloid shift with increased neutrophil counts

enlarged lymph nodes ( J:135172 )

• 70% of mutants exhibit enlarged lymph nodes

liver/biliary system

enlarged liver ( J:135172 )

• hepatomegaly

neoplasm

increased acute lymphoblastic leukemia incidence ( J:135172 )

• 74% of mutants develop T-lymphoblastic leukemia

increased acute promyelocytic leukemia incidence ( J:135172 )

• 26% of mutants develop acute myeloid leukemia

endocrine/exocrine glands

enlarged thymus ( J:135172 )

• 70% of mutants exhibit enlarged thymus

growth/size/body

enlarged liver ( J:135172 )

• hepatomegaly

enlarged spleen ( J:135172 )

• splenomegaly

Genotype
MGI:5912150

cn14

• Allelic Composition: Mcur1^{tm1c(KOMP)Wtsi}/Mcur1^{tm1c(KOMP)Wtsi}; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N
• Cell Lines: EPD0332_3_A12

respiratory system

decreased lung endothelial cell migration ( J:235756 )

decreased lung endothelial cell proliferation ( J:235756 )

homeostasis/metabolism

increased basal metabolism ( J:235756 )

• increased resting heat production compared with controls

cellular

decreased lung endothelial cell migration ( J:235756 )

decreased lung endothelial cell proliferation ( J:235756 )

abnormal mitochondrial physiology ( J:235756 )

• endothelial cell and fibroblast mitochondria exhibit almost no calcium uptake in response to extramitochondrial calcium ion pulses unlike control cells

Genotype
MGI:5569330

cn15

• Allelic Composition: Dcbld2^tm1Mhms/Dcbld2^tm1.1Mhms; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Decreased retinal angiogenesis in Dcbld2^tm1Mhms/Dcbld2^tm1.1Mhms Tg(Cdh5-cre)7Mlia/0 mice

cardiovascular system

abnormal retina vasculature morphology ( J:207629 )

• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice

abnormal pericyte morphology ( J:207629 )

• reduced pericyte staining

decreased angiogenesis ( J:207629 )

• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice

vision/eye

abnormal retina vasculature morphology ( J:207629 )

• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice

Genotype
MGI:5912151

cn16

• Allelic Composition: Mcu^tm1.1Jmol/Mcu^tm1.1Jmol; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

cellular

decreased lung endothelial cell migration ( J:235756 )

decreased lung endothelial cell proliferation ( J:235756 )

abnormal mitochondrial physiology ( J:235756 )

• cardiomyocytes, endothelial cells and fibroblast mitochondria exhibit almost no calcium uptake in response to extramitochondrial calcium ion pulses unlike control cells

• however, mitochondrial membrane potential is normal

respiratory system

decreased lung endothelial cell migration ( J:235756 )

decreased lung endothelial cell proliferation ( J:235756 )

Genotype
MGI:7278770

cn17

• Allelic Composition: Acvr1^tm1Glh/Acvr1⁺; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

skeleton

skeleton phenotype ( J:257905 )

N • pinch-mediated injury of the gastrocnemius or tibialis anterior hindlimb muscles of adults does not cause heterotopic ossification

Genotype
MGI:3849332

cn18

• Allelic Composition: H2ax^tm1Nus/H2ax^tm2.1Fwa; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

cardiovascular system

retina neovascularization ( J:149487 )

• hypoxia induced retinal neovascularization is decreased compared to controls

abnormal tumor vascularization ( J:149487 )

• vascularization of implanted tumors is reduced compared to controls

neoplasm

abnormal tumor vascularization ( J:149487 )

• vascularization of implanted tumors is reduced compared to controls

decreased tumor growth/size ( J:149487 )

• growth of implanted Lewis lung carcinomas is reduced compared to controls

vision/eye

retina neovascularization ( J:149487 )

• hypoxia induced retinal neovascularization is decreased compared to controls

Genotype
MGI:5566877

cn19

• Allelic Composition: Pgr^tm1.1Mlia/Pgr^tm1.1Mlia; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: 129X1/SvJ * FVB/N

reproductive system

impaired embryo implantation ( J:205553 )

♀ • 43% reduction in the number of implantation sites compared to controls

abnormal uterus physiology ( J:205553 )

♀ • change in permeability of uterine vasculature following hormone treatment (E2 + P4) is significantly reduced

♀ • increase in albumin extravasation during pregnancy is significantly reduced

cardiovascular system

abnormal vascular permeability ( J:205553 )

♀ • changes in permeability of uterine vasculature following hormone treatment (E2 + P4) and during pregnancy are significantly reduced

Genotype
MGI:5477819

cn20

• Allelic Composition: Epn1^tm1.1Wami/Epn1^tm1.1Wami; Epn2^tm1Ocr/Epn2^tm1Ocr; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: C57BL/6J * FVB/N

Reduced tumor growth in Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 and Epn1^tm1.1Wami/Epn1^tm1.1Wami Epn2^tm1Ocr/Epn2^tm1Ocr Tg(Cdh5-cre)7Mlia/0 mice

neoplasm

decreased tumor growth/size ( J:193966 )

• mice transplanted with Lewis Lung carcinoma (LLC) cells develop fewer tumors that grow at a slower rate compared with control mice

Genotype
MGI:6151086

cn21

• Allelic Composition: Adora2b^tm1Msit/Adora2b^tm1Msit; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: FVB/N

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:203572 )

N • following acute lung injury, dipyridamole-treated mice exhibit normal PMN trafficking

Genotype
MGI:7543772

cn22

• Allelic Composition: Bicra^em3Hzhg/Bicra^em3Hzhg; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: FVB/N

mortality/aging

mortality/aging ( J:335098 )

• mice exhibit normal embryonic survival

cardiovascular system

cardiovascular system phenotype ( J:335098 )

• mice exhibit normal cardiac phenotype

Genotype
MGI:3665410

tg23

• Allelic Composition: Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: FVB/N

normal phenotype

no abnormal phenotype detected ( J:106155 )

• mice are viable and fertile; no phenotypic abnormalities are detected