Phenotypes associated with this allele

• Allele Symbol: Plod3^tm1Rmyl
• Allele Name: targeted mutation 1, Raili Myllyla
• Allele ID: MGI:3620600
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plod3^tm1Rmyl/Plod3^tm1Rmyl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3620940

Genotype
MGI:3620940

hm1

• Allelic Composition: Plod3^tm1Rmyl/Plod3^tm1Rmyl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:106510 )

• all die around E9.5

embryo

embryonic growth retardation ( J:106510 )

abnormal neural tube morphology ( J:106510 )

• the basement membrane is absent

abnormal Reichert's membrane morphology ( J:106510 )

• abnormal type IV collagen staining

nervous system

abnormal neural tube morphology ( J:106510 )

• the basement membrane is absent

cardiovascular system

abnormal vascular endothelial cell morphology ( J:106510 )

• the basement membranes are absent, the endoplasmic reticulum is dilated, apoptosis is increased, and ruptures of the endothelial cell layer are seen

increased vasodilation ( J:106510 )

• dilated blood vessels especially around the sinus venosus

growth/size/body

embryonic growth retardation ( J:106510 )

muscle

increased vasodilation ( J:106510 )

• dilated blood vessels especially around the sinus venosus

cellular

impaired basement membrane formation ( J:106510 )

• the basement membranes of the neural tube and vascular endothelial cells are absent

• type IV collagen is seen inside the cells rather than in the basement membrane