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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lmnatm2Lgf
targeted mutation 2, Loren G Fong
MGI:3620627
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lmnatm2Lgf/Lmnatm2Lgf involves: 129S4/SvJae * C57BL/6 MGI:3620905
ht2
 		Lmnatm2Lgf/Lmnatm7Lgf involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4840106
ht3
 		Lmnatm1Stw/Lmnatm2Lgf involves: 129S1/Sv * 129S4/SvJae * C57BL/6 MGI:3620906
cx4
 		Lmnatm2Lgf/Lmna+
Zmpste24tm1Sgy/Zmpste24tm1Sgy 		involves: 129S4/SvJae * C57BL/6 MGI:3620908


Genotype
MGI:3620905
hm1
Allelic
Composition		 Lmnatm2Lgf/Lmnatm2Lgf
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm2Lgf mutation (0 available); any Lmna mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:106473 )
• viable and fertile with normal growth, muscle strength, and bone morphology




Genotype
MGI:4840106
ht2
Allelic
Composition		 Lmnatm2Lgf/Lmnatm7Lgf
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm2Lgf mutation (0 available); any Lmna mutation (84 available)
Lmnatm7Lgf mutation (0 available); any Lmna mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular




Genotype
MGI:3620906
ht3
Allelic
Composition		 Lmnatm1Stw/Lmnatm2Lgf
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm1Stw mutation (3 available); any Lmna mutation (84 available)
Lmnatm2Lgf mutation (0 available); any Lmna mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:106473 )
• viable and fertile with normal growth and muscle strength




Genotype
MGI:3620908
cx4
Allelic
Composition		 Lmnatm2Lgf/Lmna+
Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm2Lgf mutation (0 available); any Lmna mutation (84 available)
Zmpste24tm1Sgy mutation (2 available); any Zmpste24 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:106473 )
N
• no bone fractures or other skeletal abnormalities are seen

cellular
cellular phenotype ( J:106473 )
N
• far fewer misshapen nuclei in MEFs

growth/size/body
growth/size/body region phenotype ( J:106473 )
N
• normal growth

muscle
muscle phenotype ( J:106473 )
N
• muscle strength is similar to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory