Phenotypes associated with this allele

• Allele Symbol: Bmp2^tm1.1Jfm
• Allele Name: targeted mutation 1.1, James F Martin
• Allele ID: MGI:3620971
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmp2^tm1.1Jfm/Bmp2^tm1.1Jfm	Not Specified	MGI:3620972
ht2	Bmp2^tm1Jfm/Bmp2^tm1.1Jfm	involves: 129S4/SvJaeSor	MGI:3620973

Genotype
MGI:3620972

hm1

• Allelic Composition: Bmp2^tm1.1Jfm/Bmp2^tm1.1Jfm
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:99582 )

• phenotype is stated to be similar to that of Bmp2^tm1Brd homozygotes which die between E7 and E10.5; however, the embryonic stage at which lethality occurs is not specified in J:99582

cardiovascular system

abnormal heart development ( J:99582 )

• at E7.5, homozygotes display a poorly developed primitive heart structure

nervous system

abnormal neural tube morphology ( J:99582 )

• at E7.5, the mutant head folds are shown to bend forward

embryo

abnormal neural tube morphology ( J:99582 )

• at E7.5, the mutant head folds are shown to bend forward

Genotype
MGI:3620973

ht2

• Allelic Composition: Bmp2^tm1Jfm/Bmp2^tm1.1Jfm
• Genetic Background: involves: 129S4/SvJaeSor

normal phenotype

no abnormal phenotype detected ( J:99582 )

• compound heterozygous mutant mice are viable, fertile and phenotypically normal