Phenotypes associated with this allele

• Allele Symbol: Ptpn11^tm2Bgn
• Allele Name: targeted mutation 2, Benjamin G Neel
• Allele ID: MGI:3621004
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptpn11^tm2Bgn/Ptpn11^tm2Bgn	involves: 129S4/SvJae	MGI:3621558

Genotype
MGI:3621558

hm1

• Allelic Composition: Ptpn11^tm2Bgn/Ptpn11^tm2Bgn
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:106624 )

• numbers of blastocysts are normal at E3.5, but few embryos can be detected at E6.5 or 7.5

• no embryos detected at E8.5

embryo

disorganized embryonic tissue ( J:106624 )

• implanted embryos are poorly organized, extensively necrotic and show no evidence of appropriate tissue differentiation

inner cell mass degeneration ( J:106624 )

• in cultured mutant blastocysts, after 3 days, catastrophic cell loss is seen with only a thin epitheloid layer remaining