Analysis Tools|
Allele Symbol Allele Name Allele ID |
Sfrp1tm1Aksh targeted mutation 1, Akihiko Shimono MGI:3621116 |
| Summary |
9 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit an anterior-posterior elongation defect that is enhanced in the trunk relative to that observed in Sfrp1tm1Aksh/Sfrp1tm1Aksh Sfrp2tm1Aksh/Sfrp2tm1Aksh Sfrp5tm1Aksh/Sfrp5+ mice
• at late head-fold stage, mice exhibit abnormal convergence and extension
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 62% of mice exhibit spina bifida
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• 62% of mice exhibit spina bifida
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 13% of mice exhibit spina bifida
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• 13% of mice exhibit spina bifida
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryos die around E16.5
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• embryos have defective posterior axis extension detectable by increased thickness of the mesoderm layer in the posterior region
(J:106551)
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• entire body axis is shortened
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• results suggest somites 11-23 are fused, and/or reduced in number
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• regular somites smaller than normal are generated in a posterior region near the hindlimb and the forelimb levels
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• at E9.5, there is randomized or incomplete segmentation of somites
(J:106551)
• at E10.5,there is a segmentation defect in the middle of the trunk; there is randomized segmentation after the eleventh somite in the region between the forelimb and the hindlimb
(J:106551)
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• craniofacial abnormalities are visible
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• embryos exhibit syndactyly detectable at E14.5, primarily in the anterior region of the right hindlimb. rarely on the left hindlimb
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• mutant embryos display limb outgrowth defects
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• thoracic region is severely shortened, and the number of thoracic vertebrae is reduced from 13 to 5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die by E12.5
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• mice exhibit more severe anterior-posterior axis defects than in Sfrp1tm1Aksh Sfrp2tm1Aksh homozygotes
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• at E9.5
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• at E8.5, fused small somites are present
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• at E8.5, fused small somites are present
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• at E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% of mice exhibit irregular somatic segmentation and indistinct intersomitic boundaries
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• intersomitic boundaries are absent in the posterior portion
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pre-somitic mesoderm is reduced
• however, the notochord and tail bud mesoderm are present
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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