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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sfrp2tm1Aksh
targeted mutation 1, Akihiko Shimono
MGI:3621117
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sfrp2tm1Aksh/Sfrp2tm1Aksh involves: 129 * C57BL/6 MGI:3621483
cx2
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Sfrp5tm1Aksh/Sfrp5+
Vangl2Lp/Vangl2+
involves: 129 * A * C57BL/6 * LPT/LeJ MGI:3795553
cx3
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2+
Sfrp5tm1Aksh/Sfrp5tm1Aksh
Vangl2Lp/Vangl2+
involves: 129 * A * C57BL/6 * LPT/LeJ MGI:3795555
cx4
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
involves: 129 * C57BL/6 MGI:3621482
cx5
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Sfrp5tm1Aksh/Sfrp5+
involves: 129 * C57BL/6 MGI:3795554
cx6
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Sfrp5tm1Aksh/Sfrp5tm1Aksh
involves: 129 * C57BL/6 MGI:3795557
cx7
Dkk1tm1Sia/Dkk1tm1Sia
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2+
involves: 129 * C57BL/6 * CBA MGI:3795551
cx8
Dkk1tm1Sia/Dkk1tm1Sia
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
involves: 129 * C57BL/6 * CBA MGI:3795552


Genotype
MGI:3621483
hm1
Allelic
Composition
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• 3% of homozygotes display hindlimb syndactyly




Genotype
MGI:3795553
cx2
Allelic
Composition
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Sfrp5tm1Aksh/Sfrp5+
Vangl2Lp/Vangl2+
Genetic
Background
involves: 129 * A * C57BL/6 * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1tm1Aksh mutation (1 available); any Sfrp1 mutation (19 available)
Sfrp2tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
Sfrp5tm1Aksh mutation (0 available); any Sfrp5 mutation (27 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• mice exhibit an anterior-posterior elongation defect that is enhanced in the trunk relative to that observed in Sfrp1tm1Aksh/Sfrp1tm1Aksh Sfrp2tm1Aksh/Sfrp2tm1Aksh Sfrp5tm1Aksh/Sfrp5+ mice
• at late head-fold stage, mice exhibit abnormal convergence and extension

nervous system




Genotype
MGI:3795555
cx3
Allelic
Composition
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2+
Sfrp5tm1Aksh/Sfrp5tm1Aksh
Vangl2Lp/Vangl2+
Genetic
Background
involves: 129 * A * C57BL/6 * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1tm1Aksh mutation (1 available); any Sfrp1 mutation (19 available)
Sfrp2tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
Sfrp5tm1Aksh mutation (0 available); any Sfrp5 mutation (27 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 62% of mice exhibit spina bifida

embryo
• 62% of mice exhibit spina bifida




Genotype
MGI:3621482
cx4
Allelic
Composition
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1tm1Aksh mutation (1 available); any Sfrp1 mutation (19 available)
Sfrp2tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• embryos have defective posterior axis extension detectable by increased thickness of the mesoderm layer in the posterior region (J:106551)
• entire body axis is shortened
• results suggest somites 11-23 are fused, and/or reduced in number
• regular somites smaller than normal are generated in a posterior region near the hindlimb and the forelimb levels
• at E9.5, there is randomized or incomplete segmentation of somites (J:106551)
• at E10.5,there is a segmentation defect in the middle of the trunk; there is randomized segmentation after the eleventh somite in the region between the forelimb and the hindlimb (J:106551)

homeostasis/metabolism
• embryos are edematous

craniofacial
• craniofacial abnormalities are visible

limbs/digits/tail
• embryos exhibit syndactyly detectable at E14.5, primarily in the anterior region of the right hindlimb. rarely on the left hindlimb
• mutant embryos display limb outgrowth defects

skeleton
• thoracic region is severely shortened, and the number of thoracic vertebrae is reduced from 13 to 5




Genotype
MGI:3795554
cx5
Allelic
Composition
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Sfrp5tm1Aksh/Sfrp5+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1tm1Aksh mutation (1 available); any Sfrp1 mutation (19 available)
Sfrp2tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
Sfrp5tm1Aksh mutation (0 available); any Sfrp5 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo




Genotype
MGI:3795557
cx6
Allelic
Composition
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Sfrp5tm1Aksh/Sfrp5tm1Aksh
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1tm1Aksh mutation (1 available); any Sfrp1 mutation (19 available)
Sfrp2tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
Sfrp5tm1Aksh mutation (0 available); any Sfrp5 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• mice exhibit more severe anterior-posterior axis defects than in Sfrp1tm1Aksh Sfrp2tm1Aksh homozygotes
• at E9.5
• at E8.5, fused small somites are present
• at E8.5, fused small somites are present

nervous system
• at E9.5

growth/size/body




Genotype
MGI:3795551
cx7
Allelic
Composition
Dkk1tm1Sia/Dkk1tm1Sia
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2+
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Sia mutation (0 available); any Dkk1 mutation (18 available)
Sfrp1tm1Aksh mutation (1 available); any Sfrp1 mutation (19 available)
Sfrp2tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• intersomitic boundaries are absent in the posterior portion




Genotype
MGI:3795552
cx8
Allelic
Composition
Dkk1tm1Sia/Dkk1tm1Sia
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Sia mutation (0 available); any Dkk1 mutation (18 available)
Sfrp1tm1Aksh mutation (1 available); any Sfrp1 mutation (19 available)
Sfrp2tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• pre-somitic mesoderm is reduced
• however, the notochord and tail bud mesoderm are present





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory