cardiovascular system
• myocytes enlarged
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• no hypertension seen
• hypertrophy starts to develop around 2 months of age
• consistently seen at 12 months of age
• heart weight/body weight ratio increased by 77%
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• posterior wall thickness increased 19%
• mass increased 70%
• end diastolic left ventricular diameter increased 42%
• end systolic left ventricular diameter increased 51%
|
growth/size/body
• no hypertension seen
• hypertrophy starts to develop around 2 months of age
• consistently seen at 12 months of age
• heart weight/body weight ratio increased by 77%
|
• end diastolic left ventricular diameter increased 42%
• end systolic left ventricular diameter increased 51%
• posterior wall thickness increased 19%
• mass increased 70%
|
• body weight is slightly decreased or normal
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• in 80% of homozygotes over 12 months of age
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immune system
• in 80% of homozygotes over 12 months of age
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• in animals over 12 months of age
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• in animals over 12 months of age
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neoplasm
• myeloid leukemia after 12 months of age
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• after 12 months of age
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hematopoietic system
• in 80% of homozygotes over 12 months of age
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• in animals over 12 months of age
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muscle
• myocytes enlarged
|
• end diastolic left ventricular diameter increased 42%
• end systolic left ventricular diameter increased 51%
• posterior wall thickness increased 19%
• mass increased 70%
|