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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hmga1tm1Afus
targeted mutation 1, Alfredo Fusco
MGI:3621126
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hmga1tm1Afus/Hmga1tm1Afus involves: 129S7/SvEvBrd * C57BL/6 MGI:3621547
ht2
Hmga1tm1Afus/Hmga1+ involves: 129S7/SvEvBrd * C57BL/6 MGI:3621548


Genotype
MGI:3621547
hm1
Allelic
Composition
Hmga1tm1Afus/Hmga1tm1Afus
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmga1tm1Afus mutation (0 available); any Hmga1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• no hypertension seen
• hypertrophy starts to develop around 2 months of age
• consistently seen at 12 months of age
• heart weight/body weight ratio increased by 77%
• posterior wall thickness increased 19%
• mass increased 70%
• end diastolic left ventricular diameter increased 42%
• end systolic left ventricular diameter increased 51%

growth/size/body
• no hypertension seen
• hypertrophy starts to develop around 2 months of age
• consistently seen at 12 months of age
• heart weight/body weight ratio increased by 77%
• end diastolic left ventricular diameter increased 42%
• end systolic left ventricular diameter increased 51%
• posterior wall thickness increased 19%
• mass increased 70%
• body weight is slightly decreased or normal
• in 80% of homozygotes over 12 months of age

immune system
• in 80% of homozygotes over 12 months of age
• in animals over 12 months of age
• in animals over 12 months of age

neoplasm
• myeloid leukemia after 12 months of age

hematopoietic system
• in 80% of homozygotes over 12 months of age
• in animals over 12 months of age

muscle
• end diastolic left ventricular diameter increased 42%
• end systolic left ventricular diameter increased 51%
• posterior wall thickness increased 19%
• mass increased 70%




Genotype
MGI:3621548
ht2
Allelic
Composition
Hmga1tm1Afus/Hmga1+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmga1tm1Afus mutation (0 available); any Hmga1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• no hypertension seen
• heart weight/body weight ratio increased by 35%

immune system
• in 78% of heterozygotes over 12 months of age

hematopoietic system
• in 78% of heterozygotes over 12 months of age

growth/size/body
• no hypertension seen
• heart weight/body weight ratio increased by 35%
• in 78% of heterozygotes over 12 months of age





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory