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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(MMTV-Myc)#Led
transgene insertion, Philip Leder
MGI:3621200
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Hunktm1Lach/Hunktm1Lach
Tg(MMTV-Myc)#Led/0
involves: 129P2/OlaHsd * C57BL/6J * CD-1 MGI:4361150
cx2
Hunktm1Lach/Hunk+
Tg(MMTV-Myc)#Led/0
involves: 129P2/OlaHsd * C57BL/6J * CD-1 MGI:4361151


Genotype
MGI:4361150
cx1
Allelic
Composition
Hunktm1Lach/Hunktm1Lach
Tg(MMTV-Myc)#Led/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hunktm1Lach mutation (0 available); any Hunk mutation (44 available)
Tg(MMTV-Myc)#Led mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• while tumor latency, multiplicity and growth rate are similar to controls, the fraction of mice with lung metastases is about 5 fold lower compared to transgenic mice wild-type for Hunk
• a decrease in metastases is also seen when primary tumors are transplanted in nude mice




Genotype
MGI:4361151
cx2
Allelic
Composition
Hunktm1Lach/Hunk+
Tg(MMTV-Myc)#Led/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hunktm1Lach mutation (0 available); any Hunk mutation (44 available)
Tg(MMTV-Myc)#Led mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• while tumor latency, multiplicity and growth rate are similar to controls, the fraction of mice with lung metastases is reduced compared to transgenic mice wild-type for Hunk but increased compared to transgenic mice that are homozygous for the mutant allele





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory