Analysis Tools
homeostasis/metabolism
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• under pressure-overload stress via transverse aortic constriction (TAC), mice receiving zinc in drinking water, show greatly reduced interstitial nonmyocyte proliferation in the left ventricle, attenuated collagen deposition in the left ventricle, increase in left ventricular end systolic diameter and end systolic and end diastolic volumes, decreased ejection fraction and fractional shortening
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cardiovascular system
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• at 28 and 120 days post-transverse aortic constriction (TAC), zinc-treated mice show no increase in collagen deposition in the left ventricle as is seen controls indicating attenuation of TAC-induced collagen deposition
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• pressure-overload stress via TAC promotes left ventricular dilation in zinc-treated mice
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• transverse aortic constriction of zinc-treated mice results in dilated cardiomyopathy, with mice showing exacerbated TAC-induced left ventricle dilation and dysfunction, but not left ventricle hypertrophy
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• TAC-induced decrease in ejection fraction and fractional shortening are exacerbated in zinc-treated mice compared to controls
• however, cardiac output and heart rate are not different from controls following TAC
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• at 120 days post-TAC, left ventricular end diastolic diameter and end diastolic volume are greater in zinc-treated mice than in controls
• TAC-induced increases in left ventricular end systolic diameter and end systolic volume are greater in zinc-treated mice than in controls at 120 days post-TAC
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• under pressure-overload stress via transverse aortic constriction (TAC), mice receiving zinc in drinking water, show greatly reduced interstitial nonmyocyte proliferation in the left ventricle, attenuated collagen deposition in the left ventricle, increase in left ventricular end systolic diameter and end systolic and end diastolic volumes, decreased ejection fraction and fractional shortening
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cellular
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• TAC-induced nonmyocyte proliferation in left ventricle of zinc-treated mice is reduced 7 days post-TAC compared to controls
• however, apoptotic cell death in heart at 7 days after TAC is no different from controls
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muscle
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• transverse aortic constriction of zinc-treated mice results in dilated cardiomyopathy, with mice showing exacerbated TAC-induced left ventricle dilation and dysfunction, but not left ventricle hypertrophy
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• TAC-induced decrease in ejection fraction and fractional shortening are exacerbated in zinc-treated mice compared to controls
• however, cardiac output and heart rate are not different from controls following TAC
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| dilated cardiomyopathy | DOID:12930 |
OMIM:PS115200 |
J:158480 | |
