Phenotypes associated with this allele

• Allele Symbol: Tg(Tcra2C,Tcrb2C)1Dlo
• Allele Name: transgene insertion 1, Dennis Y Loh
• Allele ID: MGI:3621454
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fadd^tm1Wnt/Fadd^tm1Wnt Tg(Fadd)33Wnt/0 Tg(Lck-cre)I57Jxm/0 Tg(Tcra2C,Tcrb2C)1Dlo/0	involves: 129S4/SvJae * C57BL/6 * C57L * CBA * ICR * SJL	MGI:4358109
cx2	Fbn1^Tsk/Fbn1^+ Tg(Tcra2C,Tcrb2C)1Dlo/?	involves: C57BL/10 * DBA/2	MGI:5301105
tg3	Tg(Tcra2C,Tcrb2C)1Dlo/?	involves: C57BL/6 * SJL	MGI:3760747
tg4	Tg(Tcra2C,Tcrb2C)1Dlo/?	involves: C57L * DBA/2 * SJL	MGI:5002471

Genotype
MGI:4358109

cn1

• Allelic Composition: Fadd^tm1Wnt/Fadd^tm1Wnt; Tg(Fadd)33Wnt/0; Tg(Lck-cre)I57Jxm/0; Tg(Tcra2C,Tcrb2C)1Dlo/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57L * CBA * ICR * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:69617 )

increased double-negative T cell number ( J:69617 )

hematopoietic system

thymus hypoplasia ( J:69617 )

increased double-negative T cell number ( J:69617 )

endocrine/exocrine glands

thymus hypoplasia ( J:69617 )

Genotype
MGI:5301105

cx2

• Allelic Composition: Fbn1^Tsk/Fbn1⁺; Tg(Tcra2C,Tcrb2C)1Dlo/?
• Genetic Background: involves: C57BL/10 * DBA/2

integument

integument phenotype ( J:57957 )

N • dermal fibrosis fails to develop

respiratory system

emphysema ( J:57957 )

• emphysema develops as expected for heterozygous Fbn1^Tsk

Genotype
MGI:3760747

tg3

• Allelic Composition: Tg(Tcra2C,Tcrb2C)1Dlo/?
• Genetic Background: involves: C57BL/6 * SJL

immune system

abnormal CD8-positive, alpha beta T cell morphology ( J:125259 )

• CD5 levels are reduced, indicating CD8-positive T cells are being activated by self-antigen

hematopoietic system

abnormal CD8-positive, alpha beta T cell morphology ( J:125259 )

• CD5 levels are reduced, indicating CD8-positive T cells are being activated by self-antigen

Genotype
MGI:5002471

tg4

• Allelic Composition: Tg(Tcra2C,Tcrb2C)1Dlo/?
• Genetic Background: involves: C57L * DBA/2 * SJL

immune system

increased CD4-positive, alpha-beta T cell number ( J:95380 )

• 4 fold expansion in mice recovering from dermatitis at 70 days of age compared to a 28% increase in age matched controls

decreased lymphocyte cell number ( J:95380 )

• massive central depletion and peripheral neutropenia

decreased thymocyte number ( J:95380 )

• thymocytes reduced 10 fold

• double positive thymocyte numbers reduced 500 fold

• single positive cells also reduced

• virtually no CD4+ cells are found in the spleen

abnormal memory T cell physiology ( J:95380 )

• mice immunized with hen egg lysozyme fail to respond to later antigen challenge

seborrheic dermatitis ( J:95380 )

• Background Sensitivity: response increases with increasing DBA/2 contribution to the background, varying degrees of resistance on C57BL/6 or BALB/c backgrounds

• spontaneous inflammatory skin disease develops around the time of sexual maturity, within 1- 2 weeks of weaning, earlier and more severe in males

• chronic with periodic flares, typically involves ears, rostrum, and perineum

• acute disease begins in the periocular region involving edema and serous exudate

• swelling of the pinna and hyperkeratotic debris extending into the external auditory meatus

• recovery begins around 70 days of age and recovered mice are resistant to recurrence

integument

seborrheic dermatitis ( J:95380 )

• Background Sensitivity: response increases with increasing DBA/2 contribution to the background, varying degrees of resistance on C57BL/6 or BALB/c backgrounds

• spontaneous inflammatory skin disease develops around the time of sexual maturity, within 1- 2 weeks of weaning, earlier and more severe in males

• chronic with periodic flares, typically involves ears, rostrum, and perineum

• acute disease begins in the periocular region involving edema and serous exudate

• swelling of the pinna and hyperkeratotic debris extending into the external auditory meatus

• recovery begins around 70 days of age and recovered mice are resistant to recurrence

abnormal dermis papillary layer morphology ( J:95380 )

• edematous dermal papillae

• neutrophilic abscesses

thick epidermis ( J:95380 )

• epidermal thickening from 1-2 layers to 10 layers

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:95380 )

• 4 fold expansion in mice recovering from dermatitis at 70 days of age compared to a 28% increase in age matched controls

decreased lymphocyte cell number ( J:95380 )

• massive central depletion and peripheral neutropenia

decreased thymocyte number ( J:95380 )

• thymocytes reduced 10 fold

• double positive thymocyte numbers reduced 500 fold

• single positive cells also reduced

• virtually no CD4+ cells are found in the spleen

abnormal memory T cell physiology ( J:95380 )

• mice immunized with hen egg lysozyme fail to respond to later antigen challenge

endocrine/exocrine glands

decreased thymocyte number ( J:95380 )

• thymocytes reduced 10 fold

• double positive thymocyte numbers reduced 500 fold

• single positive cells also reduced

• virtually no CD4+ cells are found in the spleen