Analysis Tools
immune system
hematopoietic system
endocrine/exocrine glands
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Allele Symbol Allele Name Allele ID |
Tg(Tcra2C,Tcrb2C)1Dlo transgene insertion 1, Dennis Y Loh MGI:3621454 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• dermal fibrosis fails to develop
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CD5 levels are reduced, indicating CD8-positive T cells are being activated by self-antigen
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• CD5 levels are reduced, indicating CD8-positive T cells are being activated by self-antigen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 4 fold expansion in mice recovering from dermatitis at 70 days of age compared to a 28% increase in age matched controls
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• massive central depletion and peripheral neutropenia
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• thymocytes reduced 10 fold
• double positive thymocyte numbers reduced 500 fold
• single positive cells also reduced
• virtually no CD4+ cells are found in the spleen
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• mice immunized with hen egg lysozyme fail to respond to later antigen challenge
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• Background Sensitivity: response increases with increasing DBA/2 contribution to the background, varying degrees of resistance on C57BL/6 or BALB/c backgrounds
• spontaneous inflammatory skin disease develops around the time of sexual maturity, within 1- 2 weeks of weaning, earlier and more severe in males
• chronic with periodic flares, typically involves ears, rostrum, and perineum
• acute disease begins in the periocular region involving edema and serous exudate
• swelling of the pinna and hyperkeratotic debris extending into the external auditory meatus
• recovery begins around 70 days of age and recovered mice are resistant to recurrence
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• Background Sensitivity: response increases with increasing DBA/2 contribution to the background, varying degrees of resistance on C57BL/6 or BALB/c backgrounds
• spontaneous inflammatory skin disease develops around the time of sexual maturity, within 1- 2 weeks of weaning, earlier and more severe in males
• chronic with periodic flares, typically involves ears, rostrum, and perineum
• acute disease begins in the periocular region involving edema and serous exudate
• swelling of the pinna and hyperkeratotic debris extending into the external auditory meatus
• recovery begins around 70 days of age and recovered mice are resistant to recurrence
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• edematous dermal papillae
• neutrophilic abscesses
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• epidermal thickening from 1-2 layers to 10 layers
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• 4 fold expansion in mice recovering from dermatitis at 70 days of age compared to a 28% increase in age matched controls
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• massive central depletion and peripheral neutropenia
|
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• thymocytes reduced 10 fold
• double positive thymocyte numbers reduced 500 fold
• single positive cells also reduced
• virtually no CD4+ cells are found in the spleen
|
|
• mice immunized with hen egg lysozyme fail to respond to later antigen challenge
|
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• thymocytes reduced 10 fold
• double positive thymocyte numbers reduced 500 fold
• single positive cells also reduced
• virtually no CD4+ cells are found in the spleen
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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