All Phenotypes Gnasas1<tm1Jop> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gnasas1^tm1Jop
targeted mutation 1, Jo Peters
MGI:3621477

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gnasas1^tm1Jop/Gnasas1⁺	involves: 129S/SvEv	MGI:3622191
ht2	Gnasas1^tm1Jop/Gnasas1^tm1.1Jop	involves: 129S/SvEv * 129S1/Sv	MGI:4950266
cx3	Gnas^Oedsml/Gnas⁺ Gnasas1^tm1Jop/Gnasas1⁺	involves: 101/H * 129S/SvEv * C3H/HeH	MGI:3622192

Allelic Composition	Gnasas1^tm1Jop/Gnasas1⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnasas1^tm1Jop mutation (0 available); any Gnasas1 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:106793 )

• when this allele is paternally inherited heterozygotes die by P2

behavior/neurological

lethargy ( J:106793 )

• when this allele is paternally inherited heterozygotes become lethargic shortly after birth

abnormal suckling behavior ( J:106793 )

• when this allele is paternally inherited heterozygotes do not feed properly

growth/size/body

decreased body size ( J:106793 )

• when this allele is paternally inherited heterozygotes become thin shortly after birth

cellular

maternal imprinting ( J:106793 )

• when this allele is maternally inherited heterozygotes are viable and fertile

Allelic Composition	Gnasas1^tm1Jop/Gnasas1^tm1.1Jop
Genetic Background	involves: 129S/SvEv * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnasas1^tm1.1Jop mutation (0 available); any Gnasas1 mutation (6 available)
Gnasas1^tm1Jop mutation (0 available); any Gnasas1 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal DNA methylation ( J:171195 )

• when this allele is inherited maternally, some mice exhibit loss of methylation of Nespas differentially methylated region (DMR) compared with wild-type mice

Allelic Composition	Gnas^Oedsml/Gnas⁺ Gnasas1^tm1Jop/Gnasas1⁺
Genetic Background	involves: 101/H * 129S/SvEv * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnasas1^tm1Jop mutation (0 available); any Gnasas1 mutation (6 available)
Gnas^Oedsml mutation (0 available); any Gnas mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

edema ( J:106793 )

• when Nepas^tm1Jop is paternally inherited and Gnas^Oedsml-mat is maternally inherited the incidence of edema is reduced (6 of 32 develop edema) compared to mice heterozygous for Gnas^Oedsml-mat alone (20 of 20)

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