Phenotypes associated with this allele

• Allele Symbol: Runx1^{tm1(RUNX1)Gcg}
• Allele Name: targeted mutation 1, Gerard C Grosveld
• Allele ID: MGI:3621479
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Runx1^tm1(RUNX1)Gcg/Runx1^tm1(RUNX1)Gcg Tg(Mx1-cre)1Cgn/0	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3621942

Genotype
MGI:3621942

cn1

• Allelic Composition: Runx1^{tm1(RUNX1)Gcg}/Runx1^{tm1(RUNX1)Gcg}; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell derived lymphoma incidence ( J:106800 )

• start to develop T-lympoid leukemia/lymphoma about 6 months after conditional activation of the gene insert

• 39% die over the 7 months following appearance of tumors

abnormal T cell differentiation ( J:106800 )

• thymocyte growth stimulated

• conversion of double negative to double positive lymphocytes impaired

decreased double-positive T cell number ( J:106800 )

• conversion of double negative to double positive lymphocytes impaired

abnormal myelopoiesis ( J:106801 )

• increased proportion of immature myeloid cells in bone marrow

abnormal granulocyte differentiation ( J:106800 )

• differentiation of granulocytes in bone marrow blocked

decreased CD4-positive, alpha-beta T cell number ( J:106800 )

• moderate reduction in CD4 single positive cells

increased CD8-positive, alpha-beta T cell number ( J:106800 )

• increased incidence of CD8 single positive cells at the expense of CD4 positive cells

hematopoietic system

increased T cell derived lymphoma incidence ( J:106800 )

• start to develop T-lympoid leukemia/lymphoma about 6 months after conditional activation of the gene insert

• 39% die over the 7 months following appearance of tumors

abnormal T cell differentiation ( J:106800 )

• thymocyte growth stimulated

• conversion of double negative to double positive lymphocytes impaired

decreased double-positive T cell number ( J:106800 )

• conversion of double negative to double positive lymphocytes impaired

abnormal myelopoiesis ( J:106801 )

• increased proportion of immature myeloid cells in bone marrow

abnormal granulocyte differentiation ( J:106800 )

• differentiation of granulocytes in bone marrow blocked

anemia ( J:106800 )

• 10% of mice develop severe anemia

decreased CD4-positive, alpha-beta T cell number ( J:106800 )

• moderate reduction in CD4 single positive cells

increased CD8-positive, alpha-beta T cell number ( J:106800 )

• increased incidence of CD8 single positive cells at the expense of CD4 positive cells

neoplasm

increased T cell derived lymphoma incidence ( J:106800 )

• start to develop T-lympoid leukemia/lymphoma about 6 months after conditional activation of the gene insert

• 39% die over the 7 months following appearance of tumors

increased metastatic potential ( J:106800 )

• neoplastic cells from thymus are found infiltrating spleen, liver, and bone marrow

cellular

abnormal granulocyte differentiation ( J:106800 )

• differentiation of granulocytes in bone marrow blocked

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:106800 )

• start to develop T-lympoid leukemia/lymphoma about 6 months after conditional activation of the gene insert

• 39% die over the 7 months following appearance of tumors