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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rad51btm1Kmic
targeted mutation 1, Eric B Kmiec
MGI:3621480
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rad51btm1Kmic/Rad51btm1Kmic involves: 129S4/SvJae * C57BL/6J MGI:3623222
cx2
 		Rad51btm1Kmic/Rad51btm1Kmic
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J MGI:3623223


Genotype
MGI:3623222
hm1
Allelic
Composition		 Rad51btm1Kmic/Rad51btm1Kmic
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad51btm1Kmic mutation (0 available); any Rad51b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:58601 )
• severely retarded in growth as early as E5.5
• completely resorbed by E8.5
• mutant blastocyst outgrowth in culture was severely impaired




Genotype
MGI:3623223
cx2
Allelic
Composition		 Rad51btm1Kmic/Rad51btm1Kmic
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad51btm1Kmic mutation (0 available); any Rad51b mutation (25 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between somite formation and embryo turning ( J:58601 )
• embryonic development progress further than Rad51l1tm1Kmic homozygous embryo




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory