Phenotypes associated with this allele

• Allele Symbol: nmf418
• Allele Name: neuroscience mutagenesis facility, 418
• Allele ID: MGI:3621487
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	nmf418/nmf418	B6;CByJ-nmf418/J	MGI:3621641

Genotype
MGI:3621641

hm1

• Allelic Composition: nmf418/nmf418
• Genetic Background: B6;CByJ-nmf418/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:87349 )

N • despite weakness, spasms and occasional flaccidity of the hind limbs, no abnormalities were observed upon microscopic examination of fluorescent bungarotoxin, SV2 or SMI 31 labeled whole hind limb muscle mounts from a 59 day old mutant mouse

muscle spasm ( J:87349 )

• from 4.6 +/- 2.2 weeks of age, homozygous mutant mice exhibit intermittent spasms of the hind limbs, which become progressively more severe

muscle weakness ( J:87349 )

• hind limbs of older mutant mice are usually clasped close to the body, but sometimes become flaccid while the mouse is moving or sitting and may cross over one another or become intertwined

limbs/digits/tail

limbs/digits/tail phenotype ( J:87349 )

N • from 4.6 +/- 2.2 weeks of age, homozygous mice exhibit curling of the toes of the front and/or hind paws

behavior/neurological

behavior/neurological phenotype ( J:87349 )

N • despite weakness, spasms and occasional flaccidity of the hind limbs, mutant mice exhibit a brisk hind limb flexor response

limb grasping ( J:87349 )

• when lifted by the tail, a mutant mouse keeps its hind limbs clasped close to its body

nervous system

abnormal cerebellum morphology ( J:87349 )

• standard pathological analysis of two mice aged 10 and 31 days revealed thin cerebellar folia in the older mouse