Phenotypes associated with this allele

• Allele Symbol: Tnks2^tm1Susm
• Allele Name: targeted mutation 1, Susan Smith
• Allele ID: MGI:3621819
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnks2^tm1Susm/Tnks2^tm1Susm	involves: 129S/SvEv * C57BL/6	MGI:3622155

Genotype
MGI:3622155

hm1

• Allelic Composition: Tnks2^tm1Susm/Tnks2^tm1Susm
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:106917 )

• 7 of 37 homozygotes die by P20 compared to only 1 of 69 or 2 of 35 for heterozygous and wild-type mice, respectively

growth/size/body

decreased body weight ( J:106917 )

• similar weight to wild-type at birth but decreased by P6

• on average mice weigh 40% and 20% less than wild-type at P20 and P56, respectively

• a few severely affected mice weigh 50 - 60% less than wild-type and generally die before weaning

cellular

cellular phenotype ( J:106917 )

N • telomere length and the incidence of chromosome aberrations in splenocytes and thymocytes is similar to wild-type