Phenotypes associated with this allele

• Allele Symbol: Vipr2^tm1Hmh
• Allele Name: targeted mutation 1, Hansen M Hsiung
• Allele ID: MGI:3621886
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vipr2^tm1Hmh/Vipr2^tm1Hmh	involves: 129P2/OlaHsd * C57BL/6	MGI:3622281

Genotype
MGI:3622281

hm1

• Allelic Composition: Vipr2^tm1Hmh/Vipr2^tm1Hmh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased lean body mass ( J:106803 )

• at 22 weeks of age, lean mass of knockouts is increased 6-8% compared to wild-type

decreased body weight ( J:106803 )

• at 29 weeks of age, male and female mutants weigh 22 and 25% less respectively than wild-type littemates

decreased body length ( J:106803 )

• male and female knockouts are shorter by 7 and 5% respectively than wild-type littermates at 32 weeks of age

homeostasis/metabolism

increased circulating triiodothyronine level ( J:106803 )

• 9 month-old knockout animals have lower serum T3 levels compared to wild-type

increased insulin sensitivity ( J:106803 )

• knockouts show an increased insulin sensitivity when analyzed after glucose challenge

adipose tissue

decreased total body fat amount ( J:106803 )

• fat mass is decreased by 10% in female knockouts at 22 weeks of age

reproductive system

seminiferous tubule degeneration ( J:106803 )

♂ • in older males, there is evidence of mild to moderate seminiferous tubular degeneration and associated hypospermia

reduced male fertility ( J:106803 )

♂ • at 31 weeks of age, knockout males have reduced fertility

behavior/neurological

decreased food intake ( J:106803 )

• at 14-18 weeks of age, food consumption was decreased by 15% and 19% in male and female mutants respectively compared to controls

endocrine/exocrine glands

seminiferous tubule degeneration ( J:106803 )

♂ • in older males, there is evidence of mild to moderate seminiferous tubular degeneration and associated hypospermia