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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrp4tm1Her
targeted mutation 1, Joachim Herz
MGI:3621893
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lrp4tm1Her/Lrp4tm1Her involves: 129S6/SvEvTac MGI:4455051
hm2
 		Lrp4tm1Her/Lrp4tm1Her involves: 129S6/SvEvTac * C57BL/6 MGI:3622272
hm3
 		Lrp4tm1Her/Lrp4tm1Her involves: 129S/SvEvBrd * 129S6/SvEvTac * C57BL/6J MGI:5561076
cx4
 		Apptm1Dbo/Apptm1Dbo
Lrp4tm1Her/Lrp4+ 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J MGI:5561078
cx5
 		Apptm1Dbo/Apptm1Dbo
Lrp4tm1Her/Lrp4tm1Her 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J MGI:5561079
cx6
 		Aplp2tm1Dbo/Aplp2tm1Dbo
Lrp4tm1Her/Lrp4tm1Her 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J MGI:5561080
cx7
 		Apptm1Dbo/App+
Lrp4tm1Her/Lrp4tm1Her 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J MGI:5561077


Genotype
MGI:4455051
hm1
Allelic
Composition		 Lrp4tm1Her/Lrp4tm1Her
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp4tm1Her mutation (1 available); any Lrp4 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal incisor morphology ( J:156471 )
• distinct grooved incisor labial surfaces
supernumerary incisors ( J:156471 )
• over one third show supernumerary maxillary incisor tooth germs at birth
abnormal enamel morphology ( J:156471 )
• grooves on incisors result from a localized reduction of enamel on the labial surface

growth/size/body
abnormal incisor morphology ( J:156471 )
• distinct grooved incisor labial surfaces
supernumerary incisors ( J:156471 )
• over one third show supernumerary maxillary incisor tooth germs at birth
abnormal enamel morphology ( J:156471 )
• grooves on incisors result from a localized reduction of enamel on the labial surface

skeleton
abnormal incisor morphology ( J:156471 )
• distinct grooved incisor labial surfaces
supernumerary incisors ( J:156471 )
• over one third show supernumerary maxillary incisor tooth germs at birth
abnormal enamel morphology ( J:156471 )
• grooves on incisors result from a localized reduction of enamel on the labial surface




Genotype
MGI:3622272
hm2
Allelic
Composition		 Lrp4tm1Her/Lrp4tm1Her
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp4tm1Her mutation (1 available); any Lrp4 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:106811 )
• number of homozygotes identified at P5 is much lower than expected, but up to approximately E13, numbers of each genotype is as expected

embryo
thick apical ectodermal ridge ( J:106811 )
• the Fgf8-expressing AER is thickened and broadened in mutants

growth/size/body
abnormal incisor morphology ( J:106811 )
• mutants have mild craniofacial defects usually in the form of incisor defects
abnormal postnatal growth ( J:106811 )
• homozygotes show significantly reduced body weights and postnatal growth compared with wild-type and heterozygotes

limbs/digits/tail
thick apical ectodermal ridge ( J:106811 )
• the Fgf8-expressing AER is thickened and broadened in mutants
abnormal digit morphology ( J:106811 )
• examination 14 day-old mutants revealed fused digital bones and tendons, club-shaped deformities of digital tips and metaphyseal defects
polydactyly ( J:106811 )
• homozygous mice have fully penetrant polysyndactyly of both the fore- and hindlimbs;
abnormal forelimb morphology ( J:106811 )
• extensive bone fusion can be seen in the forelimb
abnormal hindlimb morphology ( J:106811 )
• extensive bone fusion can be seen in the hindlimb

craniofacial
abnormal incisor morphology ( J:106811 )
• mutants have mild craniofacial defects usually in the form of incisor defects

skeleton
abnormal incisor morphology ( J:106811 )
• mutants have mild craniofacial defects usually in the form of incisor defects
abnormal chondrocyte morphology ( J:106811 )
• at E12.5, chondrocye compaction is apparent in the fore- and hindlimbs of mutants; the digital cartilage is broadly fused in mutants as seen at P0




Genotype
MGI:5561076
hm3
Allelic
Composition		 Lrp4tm1Her/Lrp4tm1Her
Genetic
Background		 involves: 129S/SvEvBrd * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp4tm1Her mutation (1 available); any Lrp4 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuromuscular synapse morphology ( J:207796 )
• acetylcholine receptor density is reduced compared to in wild-type mice
• neuromuscular junction are smaller with reduced innervation compared to in wild-type mice
• however, neuromuscular synapses are present at E16.5




Genotype
MGI:5561078
cx4
Allelic
Composition		 Apptm1Dbo/Apptm1Dbo
Lrp4tm1Her/Lrp4+
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Dbo mutation (4 available); any App mutation (105 available)
Lrp4tm1Her mutation (1 available); any Lrp4 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:207796 )
• 6 of 45 mice die within 5 months




Genotype
MGI:5561079
cx5
Allelic
Composition		 Apptm1Dbo/Apptm1Dbo
Lrp4tm1Her/Lrp4tm1Her
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Dbo mutation (4 available); any App mutation (105 available)
Lrp4tm1Her mutation (1 available); any Lrp4 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:207796 )
• despite Mendelian ratios at E18.5, fewer than expected mice are present at weaning

nervous system
abnormal neuron differentiation ( J:207796 )
• increased nerve terminal sprouting
abnormal neuromuscular synapse morphology ( J:207796 )
• reduced size and density of acetylcholine clusters compared with either single homozygote

cellular
abnormal neuron differentiation ( J:207796 )
• increased nerve terminal sprouting




Genotype
MGI:5561080
cx6
Allelic
Composition		 Aplp2tm1Dbo/Aplp2tm1Dbo
Lrp4tm1Her/Lrp4tm1Her
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2tm1Dbo mutation (1 available); any Aplp2 mutation (32 available)
Lrp4tm1Her mutation (1 available); any Lrp4 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system




Genotype
MGI:5561077
cx7
Allelic
Composition		 Apptm1Dbo/App+
Lrp4tm1Her/Lrp4tm1Her
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Dbo mutation (4 available); any App mutation (105 available)
Lrp4tm1Her mutation (1 available); any Lrp4 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:207796 )
• 20 of 49 mice die within 5 months




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory