Phenotypes associated with this allele

• Allele Symbol: Nos1^tm2Plh
• Allele Name: targeted mutation 2, Paul L Huang
• Allele ID: MGI:3621899
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nos1^tm2Plh/Nos1^tm2Plh	Not Specified	MGI:3622116

Genotype
MGI:3622116

hm1

• Allelic Composition: Nos1^tm2Plh/Nos1^tm2Plh
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased corpora lutea number ( J:106816 )

♀ • marked decrease in the number of corpora lutea; however, when mutant ovaries are transplanted into wild-type mice the number of corpora lutea are increased

decreased ovary weight ( J:106816 )

♀ • at 6 weeks of age, ovary weight is decreased compared to wild-type

decreased testis weight ( J:106816 )

♂ • at 10 weeks of age, testis weight is decreased compared to wild-type

reduced female fertility ( J:106816 )

♀ • only 2 of 6 matings to wild-type males resulted in pregnancy compared to 5 of 6 wild-type mice

male infertility ( J:106816 )

♂

behavior/neurological

abnormal mating frequency ( J:106816 )

• males fail to mount females in the first 15 minutes after setting up matings and no vaginal plugs are seen; however, spermatogenesis is normal

homeostasis/metabolism

decreased circulating follicle stimulating hormone level ( J:106816 )

• decreased in males

increased circulating luteinizing hormone level ( J:106816 )

• increased in females but not in males

digestive/alimentary system

pyloric stenosis ( J:106816 )

• in both males and females; however no increase in plasma ketones or leptin levels are detected

enlarged stomach ( J:106816 )

growth/size/body

decreased body weight ( J:106816 )

• body weight is decreased in both males and females

endocrine/exocrine glands

decreased corpora lutea number ( J:106816 )

♀ • marked decrease in the number of corpora lutea; however, when mutant ovaries are transplanted into wild-type mice the number of corpora lutea are increased

decreased ovary weight ( J:106816 )

♀ • at 6 weeks of age, ovary weight is decreased compared to wild-type

decreased testis weight ( J:106816 )

♂ • at 10 weeks of age, testis weight is decreased compared to wild-type

nervous system

abnormal hypothalamus secretion ( J:106816 )

• increased hypothalmic gonadotropin-releasing hormone content in females