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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sp4tm2Krc
targeted mutation 2, Kenneth R Chien
MGI:3621970
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Myl2tm1(cre)Krc/Myl2+
Sp4tm2Krc/Sp4tm2Krc
involves: 129S4/SvJae MGI:3622077
cn2
Sp4tm2Krc/Sp4tm2Krc
Tg(Pax3-cre)1Joe/0
involves: C57BL/6 * SJL MGI:3622075


Genotype
MGI:3622077
cn1
Allelic
Composition
Myl2tm1(cre)Krc/Myl2+
Sp4tm2Krc/Sp4tm2Krc
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl2tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)
Sp4tm2Krc mutation (0 available); any Sp4 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• in mutants, there is a marked disorganization of a marker for cardiac Purkinje cells Cx40, with it being dispersed throughout the cell instead of localized along the cell boundaries as in wild-type




Genotype
MGI:3622075
cn2
Allelic
Composition
Sp4tm2Krc/Sp4tm2Krc
Tg(Pax3-cre)1Joe/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp4tm2Krc mutation (0 available); any Sp4 mutation (35 available)
Tg(Pax3-cre)1Joe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• in mutants, there is a marked disorganization of a marker for cardiac Purkinje cells Cx40 in the peripheral conduction system compared to wild-type and ventricular-specific null animals
• mice have abnormalities in the innervation to the AVN region
• atrial paced 2:1 atrioventricular block rates are higher in nulls compared to wild-type
• atrial effective refractory periods are lengthened in null animals

muscle
• in mutants, there is a marked disorganization of a marker for cardiac Purkinje cells Cx40 in the peripheral conduction system compared to wild-type and ventricular-specific null animals
• mice have abnormalities in the innervation to the AVN region





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory