Phenotypes associated with this allele

• Allele Symbol: Sp4^tm2.1Krc
• Allele Name: targeted mutation 2.1, Kenneth R Chien
• Allele ID: MGI:3621971
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sp4^tm2.1Krc/Sp4^tm2.1Krc	involves: 129S4/SvJae * Black Swiss	MGI:3714273

Genotype
MGI:3714273

hm1

• Allelic Composition: Sp4^tm2.1Krc/Sp4^tm2.1Krc
• Genetic Background: involves: 129S4/SvJae * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:107057 )

• mice survive to birth but display an increased incidence of perinatal death (16.7%)

growth/size/body

decreased body size ( J:107057 )

• mice are much smaller compared to wild-type or heterozygous littermates

cardiovascular system

abnormal impulse conducting system conduction ( J:107057 )

• atrial pacing results in significant increases in the Wenckebach cycle and 2:1 atrioventricular block cycle lengths

• atrial effective refractory periods are lengthened in null animals