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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igh-8tm1Aak
targeted mutation 1, Ahmed Amine Khamlichi
MGI:3622072
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Igh-8tm1Aak/Igh-8tm1Aak involves: 129S2/SvPas * C57BL/6 MGI:3639583


Genotype
MGI:3639583
hm1
Allelic
Composition		 Igh-8tm1Aak/Igh-8tm1Aak
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-8tm1Aak mutation (1 available); any Igh-8 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:107063 )
• mutants show defects in germ line transcription in class switch recombination; Igamma3 - Cgamma3 transcripts are almost undetectable

hematopoietic system
abnormal class switch recombination ( J:107063 )
• mutants show defects in germ line transcription in class switch recombination; Igamma3 - Cgamma3 transcripts are almost undetectable




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory