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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrp3tm1Vmd
targeted mutation 1, Vishva M Dixit
MGI:3622094
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrp3tm1Vmd/Nlrp3tm1Vmd B6.B6N-Nlrp3tm1Vmd MGI:5468973
hm2
 		Nlrp3tm1Vmd/Nlrp3tm1Vmd involves: C57BL/6N MGI:3625288
cx3
 		Nlrc4tm1Vmd/Nlrc4tm1Vmd
Nlrp3tm1Vmd/Nlrp3tm1Vmd 		C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd MGI:5428938
cx4
 		Nlrc4em2Vnce/Nlrc4em2Vnce
Nlrp3tm1Vmd/Nlrp3tm1Vmd 		involves: C57BL/6J * C57BL/6N MGI:6509152
cx5
 		Nlrc4em1Vnce/Nlrc4em1Vnce
Nlrp3tm1Vmd/Nlrp3tm1Vmd 		involves: C57BL/6J * C57BL/6N MGI:6509153
cx6
 		Del(13Naip1-Naip5)1Vnce/Del(13Naip1-Naip5)1Vnce
Nlrp3tm1Vmd/Nlrp3tm1Vmd 		involves: C57BL/6J * C57BL/6N MGI:6509155


Genotype
MGI:5468973
hm1
Allelic
Composition		 Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic
Background		 B6.B6N-Nlrp3tm1Vmd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm1Vmd mutation (0 available); any Nlrp3 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:294930 )
N
• normal inflammatory response by bone marrow derived macrophages exposed to cytosolic Legionella pneumophila flagellin
decreased circulating interleukin-1 beta level ( J:193522 )
• in response to LPS challenge in a model of acute septic shock
decreased circulating interleukin-18 level ( J:193522 )
• in response to LPS challenge in a model of acute septic shock
decreased interleukin-1 beta secretion ( J:193522 )
• from LPS-primed bone marrow-derived macrophages stimulated with E. coli, C. rodentium and C. cholerae
decreased susceptibility to endotoxin shock ( J:193522 )
• mice treated with LPS challenge in a model of acute septic shock exhibit reduced serum levels of IL1b and IL18 compared with controls
• however, mice do not survive beyond 20 hours and serum levels of IL1a are increased

homeostasis/metabolism
decreased circulating interleukin-1 beta level ( J:193522 )
• in response to LPS challenge in a model of acute septic shock
decreased circulating interleukin-18 level ( J:193522 )
• in response to LPS challenge in a model of acute septic shock




Genotype
MGI:3625288
hm2
Allelic
Composition		 Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm1Vmd mutation (0 available); any Nlrp3 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:106976 )
• unlike macrophages from wild-type mice, macrophages from Cias1-deficient mice do not release significant amounts of Il-1beta or Il-18 when primed with LPS and treated with nigericin or maitotoxin to deplete intracellular K+
• null mice secrete much lower serum levels of Il-1beta and Il-18 after receiving a lethal LPS dose
decreased susceptibility to endotoxin shock ( J:106976 )
• in response to a lethal dose of LPS, all injected wild-type mice die within 48 hours of caspase-1-dependent endotoxic shock, but only 30% of Cias-null mice die after 72 hours
abnormal response to infection ( J:106976 )
• macrophages from null mice show reduced Il-1beta and Il-18 release and no caspase-1 activation when infected with S. aureus or Listeria compared to wild-type macrophages in culture
• S. aureus infection induces more macrophage death in cells from null animals compared to wild-type macrophages in culture




Genotype
MGI:5428938
cx3
Allelic
Composition		 Nlrc4tm1Vmd/Nlrc4tm1Vmd
Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic
Background		 C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4tm1Vmd mutation (1 available); any Nlrc4 mutation (69 available)
Nlrp3tm1Vmd mutation (0 available); any Nlrp3 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:160545 )
• in LPS-primed bone marrow derived macrophages stimulated by S. typhimurium




Genotype
MGI:6509152
cx4
Allelic
Composition		 Nlrc4em2Vnce/Nlrc4em2Vnce
Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4em2Vnce mutation (1 available); any Nlrc4 mutation (69 available)
Nlrp3tm1Vmd mutation (0 available); any Nlrp3 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased lactate dehydrogenase level ( J:294930 )
• 40-50% reduction in LDH released by bone marrow derived macrophages (BMDMs) exposed to low doses of cytosolic Legionella pneumophila flagellin whether primed with LPS or not

immune system
decreased inflammatory response ( J:294930 )
• significantly reduced inflammatory response by bone marrow derived macrophages exposed to cytosolic Legionella pneumophila flagellin whether primed with LPS or not
• severely reduced inflammatory response by bone marrow derived macrophages exposed to Salmonella Typhimurium




Genotype
MGI:6509153
cx5
Allelic
Composition		 Nlrc4em1Vnce/Nlrc4em1Vnce
Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4em1Vnce mutation (0 available); any Nlrc4 mutation (69 available)
Nlrp3tm1Vmd mutation (0 available); any Nlrp3 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased lactate dehydrogenase level ( J:294930 )
• severe reduction in LDH released by bone marrow derived macrophages exposed to Salmonella Typhimurium

immune system
decreased inflammatory response ( J:294930 )
• severe reduction in inflammatory response by bone marrow derived macrophages exposed to Salmonella Typhimurium




Genotype
MGI:6509155
cx6
Allelic
Composition		 Del(13Naip1-Naip5)1Vnce/Del(13Naip1-Naip5)1Vnce
Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13Naip1-Naip5)1Vnce mutation (2 available); any Del(13Naip1-Naip5)1Vnce mutation (1 available)
Nlrp3tm1Vmd mutation (0 available); any Nlrp3 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased lactate dehydrogenase level ( J:294930 )
• severe reduction in LDH released by bone marrow derived macrophages exposed to Salmonella Typhimurium

immune system
decreased inflammatory response ( J:294930 )
• severe reduction in inflammatory response by bone marrow derived macrophages exposed to Salmonella Typhimurium




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory