Phenotypes associated with this allele

• Allele Symbol: Hnf4a^tm2.1Mwei
• Allele Name: targeted mutation 2.1, Mary C Weiss
• Allele ID: MGI:3622274
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hnf4a^tm2.1Mwei/Hnf4a^tm2.1Mwei	involves: 129S2/SvPas * BALB/c * C57BL/6	MGI:3625883

Genotype
MGI:3625883

hm1

• Allelic Composition: Hnf4a^tm2.1Mwei/Hnf4a^tm2.1Mwei
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating bilirubin level ( J:106993 )

• serum bilirubin levels were higher only in females

decreased circulating iron level ( J:106993 )

• serum iron levels were reduced

hypokalemia ( J:106993 )

• potassium concentration were reduced by 16% only in females

abnormal lipid homeostasis ( J:106993 )

• shows non-lethal dyslipidemia

increased circulating ketone body level ( J:106993 )

• the cholesterol content in all lipoprotein fractions was diminished

decreased circulating cholesterol level ( J:106993 )

• serum cholesterol contents were decreased by 41%

decreased circulating free fatty acids level ( J:106993 )

• free fatty acid levels were slightly diminished by 24%

decreased circulating triglyceride level ( J:106993 )

• serum triglyceride contents were decreased by 53%

liver/biliary system

hepatic steatosis ( J:106993 )

• present slight hepatic steatosis in 5-month old animal