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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Galr2tm1Dgen
targeted mutation 1, Deltagen
MGI:3622325
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Galr2tm1Dgen/Galr2tm1Dgen B6.129P2-Galr2tm1Dgen MGI:3624365


Genotype
MGI:3624365
hm1
Allelic
Composition		 Galr2tm1Dgen/Galr2tm1Dgen
Genetic
Background		 B6.129P2-Galr2tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Galr2tm1Dgen mutation (2 available); any Galr2 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased thermal nociceptive threshold ( J:107144 )
• mutants display an elevated thermal threshold of the non-inured hindpaw following a thermal injury to the left hindpaw

nervous system
abnormal L5 dorsal root ganglion morphology ( J:107144 )
• 7 days after unilateral axotomy, the number of neurons in the L5 contralateral DRG is 12058 in controls, while in mutants the number of neurons is significantly reduced to 9614; in the ipsilateral DRGs, wild-type mice showed significant loss of DRG neurons (8796 vs. 12058) while in mutants there is no further neuron loss (9972 vs. 9614)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory