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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Camk2a-cre)1557Sva
transgene insertion 1557, Alcino J Silva
MGI:3622450
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Braftm1Sva/Braftm1Sva
Tg(Camk2a-cre)1557Sva/0
involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ * FVB MGI:3622479
cn2
Cacna1ctm1Ggm/Cacna1ctm1Ggm
Tg(Camk2a-cre)1557Sva/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB MGI:5446617


Genotype
MGI:3622479
cn1
Allelic
Composition
Braftm1Sva/Braftm1Sva
Tg(Camk2a-cre)1557Sva/0
Genetic
Background
involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Sva mutation (1 available); any Braf mutation (60 available)
Tg(Camk2a-cre)1557Sva mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• six month old mice have poor context discrimination although contextual conditioning is normal
• six month old mice much slower to learn the platform position in a hidden platform Morris water maze (Motor coordination normal)

nervous system
• six month old mice are deficient in the early phase of long term potentiation although there is no disruption of synaptic transmission or presynaptic plasticity




Genotype
MGI:5446617
cn2
Allelic
Composition
Cacna1ctm1Ggm/Cacna1ctm1Ggm
Tg(Camk2a-cre)1557Sva/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1ctm1Ggm mutation (0 available); any Cacna1c mutation (144 available)
Tg(Camk2a-cre)1557Sva mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 30 days after the last training session (remote memory probe) mice spend less time in the training quadrant in a hidden platform Morris water maze assay
• behavior during training is similar to wild-type controls





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory