immune system
• after week 5, mutants develop splenomegaly
|
• at 5 weeks there are increased numbers of lymphocytes and eosinophils in the blood
|
• transgenic mice have elevated levels of IgE and IgG in the blood at 5 weeks of age
|
• at week 5, mutants display hyperplasia of the lymph nodes
|
hematopoietic system
• after week 5, mutants develop splenomegaly
|
• at 5 weeks there are increased numbers of lymphocytes and eosinophils in the blood
|
• transgenic mice have elevated levels of IgE and IgG in the blood at 5 weeks of age
|
liver/biliary system
• at week 5, mutants have enlarged livers
|
hearing/vestibular/ear
scaly ears
(
J:102470
)
• at 3 weeks of age, mice display scaly and thickened ears
|
craniofacial
scaly ears
(
J:102470
)
• at 3 weeks of age, mice display scaly and thickened ears
|
integument
• ear skin of transgenics exhibits a dense dermal infiltrate
|
growth/size/body
scaly ears
(
J:102470
)
• at 3 weeks of age, mice display scaly and thickened ears
|
• at week 5, mutants have enlarged livers
|
• after week 5, mutants develop splenomegaly
|