All Phenotypes Hcn2<tm2Ldw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hcn2^tm2Ldw
targeted mutation 2, Andreas Ludwig
MGI:3623002

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hcn2^tm1Ldw/Hcn2^tm2Ldw Myl7^tm1(cre)Krc/Myl7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3623024

Allelic Composition	Hcn2^tm1Ldw/Hcn2^tm2Ldw Myl7^tm1(cre)Krc/Myl7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcn2^tm1Ldw mutation (0 available); any Hcn2 mutation (31 available)
Hcn2^tm2Ldw mutation (0 available); any Hcn2 mutation (31 available)
Myl7^tm1(cre)Krc mutation (0 available); any Myl7 mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

irregular heartbeat ( J:81398 )

• variable intervals between heart beats

abnormal sinoatrial node conduction ( J:81398 )

• sinus dysrhythmia at rest but not during spontaneous activity

• variable intervals between successive heart beats

• regular P wave in a normal PR interval indicating synoatrial node dysfunction

• 30% reduced inward current of sinoatrial cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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