Phenotypes associated with this allele

• Allele Symbol: Ednrb^tm1(tTA)Tilg
• Allele Name: targeted mutation 1, Shirley M Tilghman
• Allele ID: MGI:3623110
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ednrb^tm1(tTA)Tilg/Ednrb^tm3(tetO)Tilg	involves: 129P2/OlaHsd * 129S1/Sv	MGI:3624015

Genotype
MGI:3624015

ht1

• Allelic Composition: Ednrb^tm1(tTA)Tilg/Ednrb^{tm3(tetO)Tilg}
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

pigmentation phenotype ( J:58698 )

N • compound heterozygous mice that develop in the absence of doxycycline (dox) (Ednrb is expressed) are fully pigmented and viable

N • all, but one, compound heterozygotes born to females given dox (Ednrb expression is repressed) after E12.5 or E13.5 are normal and do not develop megacolon

absent coat pigmentation ( J:58698 )

• compound heterozygous mice that develop in the presence of dox throughout pregnancy (no expression of Ednrb) display a piebald-lethal phenotype

• all compound heterozygotes born to mothers given dox at E10.5, display the full piebald-lethal phenotype

• about 50% of compound heterozygotes born to females given dox after E11.5 are piebald-lethal, with the rest pigmented in the rostral one- to two-thirds of the body and develop megacolon

digestive/alimentary system

digestive/alimentary phenotype ( J:58698 )

N • all, but one, compound heterozygotes born to females given dox (no expression of Ednrb) after E12.5 or E13.5 are normal and do not develop megacolon

megacolon ( J:58698 )

• about 50% of compound heterozygotes born to females given dox at E11.5 develop megacolon

nervous system

abnormal enteric neuron morphology ( J:58698 )

• compound heterozygotes born to females given dox between E11.5 and E12.5 exhibit no neuroblasts beyond the coecum

integument

absent coat pigmentation ( J:58698 )

• compound heterozygous mice that develop in the presence of dox throughout pregnancy (no expression of Ednrb) display a piebald-lethal phenotype

• all compound heterozygotes born to mothers given dox at E10.5, display the full piebald-lethal phenotype

• about 50% of compound heterozygotes born to females given dox after E11.5 are piebald-lethal, with the rest pigmented in the rostral one- to two-thirds of the body and develop megacolon