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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grik1tm2Sfh
targeted mutation 2, Stephen F Heinemann
MGI:3623113
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Grik1tm2Sfh/Grik1tm2Sfh involves: 129S/SvEv * C57BL/6J MGI:3624869


Genotype
MGI:3624869
hm1
Allelic
Composition		 Grik1tm2Sfh/Grik1tm2Sfh
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grik1tm2Sfh mutation (0 available); any Grik1 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:57983 )
• homozygotes have lower body weights than Griktm3Sfh homozygotes

nervous system
abnormal glutamate-mediated receptor currents ( J:57983 )
• kainate receptor current densities are reduced by a factor of six in isolated sensory neurons from dorsal root ganglia of mutant mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory