Analysis Tools
mortality/aging
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• die between E13.5 and E14.5
(J:106927)
• mice die 1 to 2 days after developing edema
(J:130930)
|
cardiovascular system
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• thin vascular smooth muscle walls are seen at E12.5 and E13.5 but not at E11.5 due to a decrease in vascular smooth muscle cell proliferation
|
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• at E12.5 and E13.5, the compact zone is discontinuous
|
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• myocardium has a disorganized structure and the chamber appears crowded
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small heart
(
J:106927
)
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• by E13.5, heart is about 2/3 the size of wild-type
|
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• by E12.5, see a significant reduction in cell proliferation in the ventricles
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homeostasis/metabolism
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• onset of edema is at E12.5, associated with a distended fluid-filled thoracic cavity
|
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• the edema formation rapidly progresses so that by E13.5, all embryos exhibit hydrops fetalis
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lymphedema
(
J:130930
)
immune system
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• at E13.5, the jugular lymph sac is smaller than in wild-type mice despite lymphedema
• proliferation of lymphatic endothelial cells is decreased compared to in wild-type mice
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muscle
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• thin vascular smooth muscle walls are seen at E12.5 and E13.5 but not at E11.5 due to a decrease in vascular smooth muscle cell proliferation
|
|
• at E12.5 and E13.5, the compact zone is discontinuous
|
|
• myocardium has a disorganized structure and the chamber appears crowded
|
|
• by E12.5, see a significant reduction in cell proliferation in the ventricles
|
|
• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum
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digestive/alimentary system
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• onset of edema is at E12.5, associated with a distended fluid-filled thoracic cavity
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integument
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• distended skin is seen at E13.5, due to fluid accumulation in the interstitial space
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cellular
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• by E12.5, see a significant reduction in cell proliferation in the ventricles
|
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• by E13.5, see a 6-fold increase in apoptosis throughout the heart, particularly in the ventricular apex, endocardial cushion, and septum
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