Phenotypes associated with this allele

• Allele Symbol: Cln3^tm1Mkat
• Allele Name: targeted mutation 1, Martin L Katz
• Allele ID: MGI:3623134
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cln3^tm1Mkat/Cln3^tm1Mkat	involves: 129X1/SvJ * C57BL/6J	MGI:3623263

Genotype
MGI:3623263

hm1

• Allelic Composition: Cln3^tm1Mkat/Cln3^tm1Mkat
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal lysosome morphology ( J:57155 )

• by 11 weeks of age, cellular inclusions with characteristics of lysosomal storage bodies are observed in mutant brains

liver/biliary system

abnormal liver morphology ( J:57155 )

• by 11 weeks of age, cellular inclusions with characteristics of lysosomal storage bodies are observed in mutant livers

nervous system

abnormal cerebral cortex morphology ( J:57155 )

• by 11 weeks of age, cellular inclusions with characteristics of lysosomal storage bodies are observed in mutant cerebral cortical neurons

reproductive system

abnormal fertility/fecundity ( J:57155 )

• breeding success of homozygotes is significantly lower than that of wild-type or heterozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuronal ceroid lipofuscinosis 3		DOID:0110731	OMIM:204200	J:57155