Analysis Tools
mortality/aging
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• ones born alive all died by 3 weeks of age
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• homozygous mutant mice were born at a sub-Mendelian ratio
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growth/size/body
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• widespread cystic dilation of pancreatic ducts and increased cell proliferation
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kidney cyst
(
J:107331
)
|
• translucent and minute cystic structures throughout the renal cortex and medulla
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• ones born alive are small and sickly
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• ones born alive had markedly swollen abdomen
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• a pronounced distention of their flanks caused by severe bilateral renomegaly within a few days of birth
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renal/urinary system
kidney cyst
(
J:107331
)
|
• translucent and minute cystic structures throughout the renal cortex and medulla
|
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• a pronounced distention of their flanks caused by severe bilateral renomegaly within a few days of birth
|
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• numerous proliferating cells lined the cystic medullary collecting ducts as well as the cortical tubules and cystic glomeruli
• exhibited abnormal development of renal epithelial tubule structures
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liver/biliary system
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• in the liver the portal tracts were prominent
• ductal plate malformation were present in the biliary tract
|
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• exhibited abnormal development of hepatic epithelial tubule structures
• the majority of epithelial cells lining the gall bladder and some extrahepatic bile ducts are proliferating
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• extrahepatic bile ducts were dilated
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• severely distended gall bladder, associated with a multifocal acute suppurative cholangitis
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• multifocal acute suppurative cholangitis
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endocrine/exocrine glands
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• in the liver the portal tracts were prominent
• ductal plate malformation were present in the biliary tract
|
|
• exhibited abnormal development of hepatic epithelial tubule structures
• the majority of epithelial cells lining the gall bladder and some extrahepatic bile ducts are proliferating
|
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• extrahepatic bile ducts were dilated
|
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• severely distended gall bladder, associated with a multifocal acute suppurative cholangitis
|
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• exhibited abnormal development of pancreatic epithelial tubule structures
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• very small and consisted of dilated ducts and cysts surrounded by reduced amounts of parenchymal tissue
|
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• widespread cystic dilation of pancreatic ducts and increased cell proliferation
|
vision/eye
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• exhibit a paucity of outer segments at all retinal locations at postnatal day 9
• disks that were present appeared rudimentary at postnatal day 9
• lacked any detectable cone outer segments at postnatal day 13
• failed to show specific rod staining in outer segments at postnatal day 13
|
|
• dramatic increase in apoptotic cells in the outer nuclear layer at postnatal day 13
|
nervous system
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• exhibit a paucity of outer segments at all retinal locations at postnatal day 9
• disks that were present appeared rudimentary at postnatal day 9
• lacked any detectable cone outer segments at postnatal day 13
• failed to show specific rod staining in outer segments at postnatal day 13
|
immune system
|
• multifocal acute suppurative cholangitis
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autosomal recessive polycystic kidney disease | DOID:0110861 | J:107331 | ||
